Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.
Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.
复制标题
DOI：
10.1016/j.expneurol.2011.11.047
复制
发表时间：
2013-06
影响因子：
5.3
通讯作者：
Frazier, Charles J.
中科院分区：
文献类型：
--
作者：
Hofmann, Mackenzie E.;Frazier, Charles J.
从大麻植物中分离出的植物大麻素在医学上具有广泛的潜力，几个世纪以来一直受到广泛认可。据推测，这些脂溶性信号分子在中枢和外周神经系统中发挥其作用，在很大程度上通过与代谢型大麻素受体的直接相互作用。这些相同的受体也被多种内源性大麻素靶向，包括2-花生四烯酸甘油和大麻素。在过去的十年中，我们对内源性脂质信号系统的细胞和突触生理学的理解取得了巨大的进展。知识的增加使我们更好地准备仔细评估天然和合成大麻素在治疗各种神经系统疾病中的潜力。在癫痫的情况下，靶向内源性大麻素信号传导系统的治疗方法的长期兴趣，在很大程度上，没有得到很好的证明，从人类癫痫患者的临床数据。然而，基础科学实验已经清楚地表明内源性大麻素信号系统在神经元兴奋性的时刻调节中起着关键作用。此外，在广泛的体外和体内癫痫模型中，这些系统可以改变癫痫样活动，也可以被癫痫样活动改变。总的来说，这些观察结果表明，在治疗人类癫痫中，内源性大麻素信号传导系统的有效治疗调节具有明确的潜力，事实上，进一步突出了实现这一目标需要解决的关键障碍。
Phytocannabinoids isolated from the cannabis plant have broad potential in medicine that has been well recognized for many centuries. It is presumed that these lipid soluble signaling molecules exert their effects in both the central and peripheral nervous system in large part through direct interaction with metabotropic cannabinoid receptors. These same receptors are also targeted by a variety of endogenous cannabinoids including 2-arachidonoyl glycerol and anandamide. Significant effort over the last decade has produced an enormous advance in our understanding of both the cellular and the synaptic physiology of endogenous lipid signaling systems. This increase in knowledge has left us better prepared to carefully evaluate the potential for both natural and synthetic cannabinoids in the treatment of a variety of neurological disorders. In the case of epilepsy, long standing interest in therapeutic approaches that target endogenous cannabinoid signaling systems are, for the most part, not well justified by available clinical data from human epileptics. Nevertheless, basic science experiments have clearly indicated a key role for endogenous cannabinoid signaling systems in moment to moment regulation of neuronal excitability. Further it has become clear that these systems can both alter and be altered by epileptiform activity in a wide range of in vitro and in vivo models of epilepsy. Collectively these observations suggest clear potential for effective therapeutic modulation of endogenous cannabinoid signaling systems in the treatment of human epilepsy, and in fact, further highlight key obstacles that would need to be addressed to reach that goal.
登录
查看更多内容
影响因子：
4.7
作者：
Blair, Robert E.;Deshpande, Laxmikant S.;Sombati, Sompong;Elphick, Maurice R.;Martin, Billy R.;DeLorenzo, Robert J.
通讯作者：
DeLorenzo, Robert J.
影响因子：
5.3
作者：
Bhaskaran, Muthu D.;Smith, Bret N.
通讯作者：
Smith, Bret N.
影响因子：
82.9
作者：
Chen, K;Baram, TZ;Soltesz, I
通讯作者：
Soltesz, I
影响因子：
25
作者：
Carlson, G;Wang, Y;Alger, BE
通讯作者：
Alger, BE
影响因子：
2.2
作者：
Bahremand, Arash;Nasrabady, Sara Ebrahimi;Dehpour, Ahmad Reza
通讯作者：
Dehpour, Ahmad Reza