Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause.
Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause.
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DOI：
10.1017/jns.2023.75
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发表时间：
2023
影响因子：
2.5
通讯作者：
Samavat, Hamed
中科院分区：
文献类型：
--
作者：
Green, Lauren;Byham-Gray, Laura;Kurzer, Mindy;Samavat, Hamed
研究表明，脂联素，瘦素和遗传多态性，如儿茶酚-O-甲基转移酶（COMT）基因型可能在血压状态中发挥不可或缺的作用，从而心血管健康。这是一个领域，特别是对绝经后妇女的重要性，然而，目前的文献调查这些协会是有限的。本研究是对明尼苏达绿色茶试验（MGTT）基线数据（N 237）的横断面二次分析。本研究探讨血浆脂联素、瘦素和COMT基因型与血压指标的关系。血浆脂联素和瘦素后，获得过夜禁食至少10小时，并通过放射免疫分析法测定。调整潜在混杂因素后，使用多元线性回归分析关系。还研究了年龄、体重指数（BMI）类别、血压类别、抗高血压药物使用和COMT基因型对效应的影响。大多数参与者是非西班牙裔（97 - 9%）和高加索人（94 - 9%）。平均（sd）年龄和BMI分别为60 ± 7（5 ± 0）岁和28 ± 2（2 ± 9）kg/m2。校正混杂变量后，血浆脂联素、血浆瘦素和COMT基因型均与收缩压或舒张压指标无关。分层分析的结果也没有显示任何显著的相互作用或关联。根据这项研究的结果，它使用了比以前的研究更严格的统计方法，脂联素，瘦素和COMT基因型都没有在绝经后妇女的血压测量中发挥作用。
Research suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current literature investigating these associations is limited. This study was a cross-sectional secondary analysis of baseline data (N 237) from the Minnesota Green Tea Trial (MGTT). The current study explored the relationships between plasma adiponectin, leptin, and COMT genotype on blood pressure measures. Plasma adiponectin and leptin were obtained after an overnight fast of at least 10 h and were measured by the radioimmunoassay method. The relationships were analysed using multiple linear regression after adjusting for potential confounders. Effect modifications by age, body mass index (BMI) category, blood pressure category, antihypertensive medication use, and COMT genotype were also investigated. The majority of participants were non-Hispanic (97⋅9 %) and Caucasian (94⋅9 %). Mean (sd) age and BMI were 60⋅7 (5⋅0) years and 28⋅2 (2⋅9) kg/m2, respectively. After adjustment for confounding variables, neither plasma adiponectin, plasma leptin nor COMT genotype was associated with systolic or diastolic blood pressure measures. The results of stratified analyses also did not reveal any significant interactions or associations. Based on the findings of this study, which utilised more rigorous statistical methods than previous research, neither adiponectin, leptin nor COMT genotype play a role in blood pressure measures in women who are post-menopause.
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DOI：
10.1161/hypertensionaha.113.01453
发表时间：
2013-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Kim DH;Kim C;Ding EL;Townsend MK;Lipsitz LA
通讯作者：
Lipsitz LA
影响因子：
24
作者：
Colantonio LD;Booth JN 3rd;Bress AP;Whelton PK;Shimbo D;Levitan EB;Howard G;Safford MM;Muntner P
通讯作者：
Muntner P
影响因子：
8.3
作者：
Chow, Wing-Sun;Cheung, Bernard M. Y.;Lam, Karen S. L.
通讯作者：
Lam, Karen S. L.
影响因子：
3.2
作者：
Baden, Megu Y.;Yamada, Yuya;Matsuzawa, Yuji
通讯作者：
Matsuzawa, Yuji
影响因子：
11.1
作者：
Hellström, L;Wahrenberg, H;Arner, P
通讯作者：
Arner, P