Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging.
Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging.
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DOI：
10.1021/acsanm.2c03537
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发表时间：
2022-11-25
影响因子：
5.9
通讯作者：
Gallo, Juan
中科院分区：
文献类型：
--
作者：
Scialla, Stefania;Genicio, Nuria;Brito, Beatriz;Florek-Wojciechowska, Malgorzata;Stasiuk, Graeme J.;Kruk, Danuta;Banobre-Lopez, Manuel;Gallo, Juan
关键词：
超顺磁铁氧化铁纳米颗粒（SPION）和脂质基质的组合使成像，药物输送和治疗功能的整合到智能溶液纳米复合材料中。 SPION限制主要在嵌入式SPION中，然后在纳米复合材料和周围环境中产生新的相互作用。理解在真实交互（NANO）系统中规则这些相互作用的参数仍然代表着一个挑战，因此很难预测甚至解释此类系统的最终（磁性）行为。在此，提出了一项系统的研究，该研究侧重于磁性纳米复合材料作为磁共振成像（MRI）对比剂和磁性高温（MH）效应子的性能。详细研究了稳定剂和磁负荷对最终物理化学的功能（即阻断温度，特定的吸收率，松弛性）的影响。
The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail.
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