Revisiting the role of oxygen therapy in cardiac patients.

Revisiting the role of oxygen therapy in cardiac patients.
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DOI:
10.1016/j.jacc.2010.04.052
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发表时间:
2010-09-21
影响因子:
24
通讯作者:
Sinoway, Lawrence I.
Sinoway, Lawrence I.
中科院分区:
医学1区
文献类型:
--
作者:
Moradkhan, Raman;Sinoway, Lawrence I.
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在过去的世纪,由于缺乏当今先进技术的精确性,多项研究提供了关于氧疗对常氧心脏病患者影响的相互矛盾的数据。更重要的是,没有随机、盲法和对照研究显示这种治疗的益处。然而,补充氧气的使用在心脏病患者中很普遍。在这些情况下,由于需要确保充分的氧合,并且因为高氧并不被认为是有害的,因此通常会发生意外的高氧。近年来,越来越多的证据表明高氧对心血管系统的潜在不良影响。在这份报告中,我们审查的数据,检查补充氧气的影响,在常氧患者的急性表现的冠状动脉疾病(CAD)。这也是本报告的目的是强调一点,即氧气治疗可能有重大的不良生理作用,必须考虑到当它被采用。
Over the past century, lacking the precision of today’s advanced technology, multiple studies provided conflicting data on the effects of oxygen therapy in normoxic cardiac patients. More importantly, no randomized, blinded and controlled studies have shown a benefit of such treatment. Yet the use of supplemental oxygen is widespread in cardiac patients. In these conditions, inadvertent hyperoxia commonly occurs because of concerns to ensure sufficient oxygenation and because hyperoxia is not perceived to be detrimental. In recent years, there has been mounting evidence demonstrating the potential adverse effects of hyperoxia on the cardiovascular system. In this report, we review data examining the effects of supplemental oxygen in normoxic patients with acute presentations of coronary artery disease (CAD). It is also the aim of this report to emphasize the point that oxygen therapy might have major adverse physiologic effects that must be considered when it is employed.
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