Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
复制标题
体育活动联盟（MOTRPAC）的分子传感器：映射动态响应对运动的反应。
DOI：
10.1016/j.cell.2020.06.004
复制
发表时间：
2020-06-25
期刊：
影响因子：
64.5
通讯作者：
Molecular Transducers of Physical Activity Consortium
中科院分区：
文献类型：
--
作者：
Sanford JA;Nogiec CD;Lindholm ME;Adkins JN;Amar D;Dasari S;Drugan JK;Fernández FM;Radom-Aizik S;Schenk S;Snyder MP;Tracy RP;Vanderboom P;Trappe S;Walsh MJ;Molecular Transducers of Physical Activity Consortium
锻炼提供了一种强有力的生理刺激，其在多个组织之间引起串扰，当有规律地重复时（即，训练）提高生理能力，有益于许多器官系统并降低过早死亡的风险。然而，在识别运动诱导的有益健康和预防疾病的详细分子信号方面仍然存在差距。身体活动联盟（MoTrPAC）的建立是为了解决这一差距，并产生运动的分子图谱。临床前和临床研究将通过在急性和慢性运动之前和之后对多个组织进行分子探测来检查耐力和阻力运动在一系列年龄和健身水平中的全身效应。从这个多组学和生物信息学分析，运动的分子图谱将被建立。总而言之，MoTrPAC将提供一个公共数据库，预计将提高我们对运动健康益处的理解，并深入了解运动如何减轻疾病。身体活动分子传感器联盟（MoTrPAC）的目标是创建一个全面的，综合的多组学图谱，以了解啮齿动物和健康人的运动对组织的影响。
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefit health and prevent disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how activity mitigates disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people.
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DOI：
10.1093/bioinformatics/btv228
发表时间：
2015-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Amar D;Yekutieli D;Maron-Katz A;Hendler T;Shamir R
通讯作者：
Shamir R
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
DOI：
10.1519/jsc.0b013e318212e415
发表时间：
2011-11-01
影响因子：
3.2
作者：
Farinatti, Paulo T. V.;Castinheiras Neto, Antonio G.
通讯作者：
Castinheiras Neto, Antonio G.
影响因子：
1.8
作者：
Radom-Aizik S;Cooper DM
通讯作者：
Cooper DM
影响因子：
3.3
作者：
GOLLNICK, PD;ARMSTRON.RB;SHEPHERD, RE
通讯作者：
SHEPHERD, RE