Bridging the Gaps: the Promise of Omics Studies in Pediatric Exercise Research.
Bridging the Gaps: the Promise of Omics Studies in Pediatric Exercise Research.
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DOI：
10.1123/pes.2015-0270
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发表时间：
2016-05
影响因子：
1.8
通讯作者：
Cooper DM
中科院分区：
文献类型：
--
作者：
Radom-Aizik S;Cooper DM
在这篇综述中，我们强调了有希望的新发现，这些发现可能会产生有用的和临床相关的见解，这些机制将运动与发展的关键时期的增长联系起来。儿童期和青春期的生长在哺乳动物中是独特的，并且是由激素和炎症介质的进化、基因表达的年龄依赖性进展和环境调节的表观遗传机制调节的动态过程。许多这些相同的过程可能会影响身体活动的分子转换器。与生长相关的分子信号是如何与运动相关的信号同步的，目前还知之甚少。“组学”的最新进展，即基因组学和表观遗传学、代谢组学和蛋白质组学，现在提供了令人兴奋的方法和工具，可以首次用于解决这一差距。将身体活动的代谢转换器与调节生长的平行过程联系起来的“健康”运动的生物学定义将改变促进身体活动最佳利用的健康政策和指导方针。
In this review, we highlight promising new discoveries that may generate useful and clinically relevant insights into the mechanisms that link exercise with growth during critical periods of development. Growth in childhood and adolescence is unique among mammals, and is a dynamic process regulated by an evolution of hormonal and inflammatory mediators, age-dependent progression of gene expression, and environmentally modulated epigenetic mechanisms. Many of these same processes likely affect molecular transducers of physical activity. How the molecular signaling associated with growth is synchronized with signaling associated with exercise is poorly understood. Recent advances in “omics,” namely, genomics and epigenetics, metabolomics, and proteomics, now provide exciting approaches and tools that can be used for the first time to address this gap. A biologic definition of “healthy” exercise that links the metabolic transducers of physical activity with parallel processes that regulate growth will transform health policy and guidelines that promote optimal use of physical activity.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1249/mss.0b013e3181b07c39
发表时间：
2010-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Nindl, Bradley C.
通讯作者：
Nindl, Bradley C.