Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in Drosophila melanogaster.
Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in Drosophila melanogaster.
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Dme-Hsa 疾病数据库 (DHDD)：果蝇中保守的人类疾病相关 miRNA 及其靶向基因
DOI：
10.3390/ijms19092642
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发表时间：
2018-09-06
影响因子：
5.6
通讯作者：
Ma F
中科院分区：
文献类型：
--
作者：
Wei G;Sun L;Qin S;Li R;Chen L;Jin P;Ma F
microRNA （miRNA）的异常表达可导致人类疾病，如癌症和神经退行性疾病。MiRNA主要通过抑制靶基因的表达来发挥其生物学功能。黑腹果蝇（D. melanogaster）是研究生物表型（包括人类疾病）背后分子机制的理想模型。在这项研究中，我们收集了人类和黑腹d.m anogaster的miRNA以及已知的人类疾病相关基因。通过“种子序列”定位，共鉴定出136个与83个D. melanogaster miRNA同源的人类疾病相关miRNA，通过DRSC整合同源预测工具鉴定出677个与734个D. melanogaster基因同源的人类疾病相关基因。此外，我们利用miRTarBase数据库和miRanda、TargetScan等目标预测软件揭示了基因与miRNA的靶关系。此外，我们可视化了这些过滤的miRNA和靶基因的相互作用网络和信号通路。最后，我们对上述所有数据和信息进行了汇总，生成了一个名为DHDD的数据库，这是第一个在黑胃d.m anogaster数据库中保存的人类疾病相关miRNA及其靶向基因的全面收集。DHDD提供了一种资源，可以方便地搜索黑胃d.m elogaster中人类疾病相关miRNA及其疾病相关靶基因及其同源物，并以视觉网络的形式方便地识别它们之间的调控关系。
Abnormal expressions of microRNA (miRNA) can result in human diseases such as cancer and neurodegenerative diseases. MiRNA mainly exert their biological functions via repressing the expression of their target genes. Drosophila melanogaster (D. melanogaster) is an ideal model for studying the molecular mechanisms behind biological phenotypes, including human diseases. In this study, we collected human and D. melanogaster miRNA as well as known human disease-related genes. In total, we identified 136 human disease-related miRNA that are orthologous to 83 D. melanogaster miRNA by mapping “seed sequence”, and 677 human disease-related genes that are orthologous to 734 D. melanogaster genes using the DRSC Integrative Ortholog Prediction Tool Furthermore, we revealed the target relationship between genes and miRNA using miRTarBase database and target prediction software, including miRanda and TargetScan. In addition, we visualized interaction networks and signalling pathways for these filtered miRNA and target genes. Finally, we compiled all the above data and information to generate a database designated DHDD This is the first comprehensive collection of human disease-related miRNA and their targeting genes conserved in a D. melanogaster database. The DHDD provides a resource for easily searching human disease-related miRNA and their disease-related target genes as well as their orthologs in D. melanogaster, and conveniently identifying the regulatory relationships among them in the form of a visual network.
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DOI：
10.1146/annurev.pathol.3.121806.151529
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
--
作者：
Lu B;Vogel H
通讯作者：
Vogel H
影响因子：
2.7
作者：
Gao, XS;Neufeld, TP;Pan, DJ
通讯作者：
Pan, DJ
影响因子：
14.9
作者：
Betel D;Wilson M;Gabow A;Marks DS;Sander C
通讯作者：
Sander C
影响因子：
14.9
作者：
Chien, S;Reiter, LT;Gribskov, M
通讯作者：
Gribskov, M
miR2Disease：人类疾病中 microRNA 失调的手动数据库
影响因子：
14.9
作者：
Jiang Q;Wang Y;Hao Y;Juan L;Teng M;Zhang X;Li M;Wang G;Liu Y
通讯作者：
Liu Y