The Cumulative Risk of Prenatal Exposures to Chemical and Non-Chemical Stressors on Birth Outcomes in Suriname.
The Cumulative Risk of Prenatal Exposures to Chemical and Non-Chemical Stressors on Birth Outcomes in Suriname.
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DOI：
10.3390/ijerph18147683
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发表时间：
2021-07-20
影响因子：
--
通讯作者：
Lichtveld MY
中科院分区：
文献类型：
--
作者：
Gokoel AR;Shankar A;Abdoel Wahid F;Hindori-Mohangoo AD;Covert HH;Wickliffe JK;Harville EW;Zijlmans WCWR;Lichtveld MY
化学和非化学压力源的累积暴露可能对出生结果产生影响。本研究的目的是研究化学物质（汞、铅、硒和锡）和非化学压力源（社会支持、感知压力、可能的抑郁和体重指数）的累积暴露对出生结果（出生体重、出生时胎龄和5分钟时的Apgar评分）的影响。研究人群是加勒比环境与职业健康研究联盟mekitamara前瞻性队列研究的一个子集（n = 384）。使用路径模型评估潜在化学构念、非化学应激源和出生结局之间的关联。结果显示，感知压力与出生体重之间存在显著的直接关系（β = - 0.17），然而，尽管感知压力与抑郁之间的关系在所有三种路径模型中都是显著的（β = 0.61），但抑郁与出生结局之间的关联并不显著。感知压力与社区参与（β = - 0.12）和个体恢复力（β = - 0.12）显著相关。BMI （β = 0.12）也与出生体重直接相关。潜在的化学构念与出生结果没有关联。我们的数据表明，需要为孕妇建立一个支持系统，让她们参与产前护理计划，以减少母亲的压力，这也可能影响抑郁，并直接改善分娩结果。育龄妇女体重管理方面的干预措施对于制止肥胖及其对生育结果的负面影响是必要的。
The cumulative exposure to chemical and non-chemical stressors may have an impact on birth outcomes. The aim of this study is to examine the cumulative exposure of a mixture of chemicals (mercury, lead, selenium and tin) and non-chemical stressors (social support, perceived stress, probable depression and BMI) on birth outcomes (birthweight, gestational age at birth, and Apgar score at 5 min). The study population is a subset (n = 384) of the Caribbean Consortium for Research in Environmental and Occupational Health–MeKiTamara prospective cohort study. Associations between the latent chemical construct, non-chemical stressors and birth outcomes were assessed using path models. The results showed a significant direct relationship between perceived stress and birthweight (β = −0.17), however even though the relationship between perceived stress and depression was significant in all three path models (β = 0.61), the association between depression and birth outcomes was not significant. Perceived stress was significantly associated with community engagement (β = −0.12) and individual resilience (β = −0.12). BMI (β = 0.12) was also significantly directly associated with birthweight. The latent chemical construct did not show an association with the birth outcomes. Our data indicate the need for the development of a support system for pregnant women by involving them in prenatal care programs to reduce maternal stress, which may also influence depression and (in)directly improve the birth outcomes. Interventions regarding weight management for women of childbearing age are necessary to halt obesity and its negative effects on birth outcomes.
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作者：
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