Reduced risks of neural tube defects and orofacial clefts with higher diet quality.
Reduced risks of neural tube defects and orofacial clefts with higher diet quality.
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DOI：
10.1001/archpediatrics.2011.185
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发表时间：
2012-02
影响因子：
--
通讯作者：
Shaw, Gary
中科院分区：
文献类型：
--
作者：
Carmichael, Suzan L.;Yang, Wei;Feldkamp, Marcia Lynn;Munger, Ronald G.;Siega-Riz, Anna Maria;Botto, Lorenzo D.;Shaw, Gary
研究是否更好的母亲饮食质量与降低某些出生缺陷的风险有关。一项多中心、以人群为基础的病例对照研究，国家出生缺陷预防研究。美国的10个参与中心。合格受试者的预计预产期为1997年10月至2005年12月。72%的病例和67%的对照母亲进行了电话采访。分析包括936例神经管缺陷（NTDs），2，475例口面裂和6，147例非畸形对照。食物频率数据用于计算地中海饮食评分（MDS）和饮食质量指数（DQI），根据现有指数建模。调整后的优势比。在协变量调整后，基于任一指数的饮食质量的提高与所研究的出生缺陷风险的降低相关。无脑儿和DQI之间的关联最强;最高与最低四分位数的比值比（OR）为0.49（95%CI 0.31，0.75）。唇裂+/-腭裂和腭裂以及DQI的OR也很显著，OR分别为0.66（0.54，0.81）和0.74（0.56，0.96）。健康的母亲饮食模式，如饮食质量评分所衡量的，与NTD和唇腭裂的风险降低有关。这些结果表明，饮食方法可以进一步降低重大出生缺陷的风险，并补充现有的强化食物和鼓励围受孕期使用多种维生素的努力。
To examine whether better maternal diet quality was associated with reduced risk for selected birth defects. A multi-center, population-based case-control study, the National Birth Defects Prevention Study. Ten participating centers in the United States. Eligible subjects’ estimated due dates were from October, 1997 through December, 2005. Telephone interviews were conducted with 72% of case and 67% of control mothers. Analyses included 936 cases with neural tube defects (NTDs), 2,475 with orofacial clefts, and 6,147 non-malformed controls. Food-frequency data were used to calculate the Mediterranean Diet Score (MDS) and Diet Quality Index (DQI), modeled after existing indices. Adjusted odds ratios. After covariate adjustment, increasing diet quality based on either index was associated with reduced risks for the birth defects studied. The strongest association was between anencephaly and DQI; the odds ratio (OR) for highest versus lowest quartile was 0.49 (95% CI 0.31, 0.75). ORs for cleft lip+/−cleft palate and cleft palate and DQI were also notable, with ORs = 0.66 (0.54, 0.81) and 0.74 (0.56, 0.96), respectively. Healthier maternal dietary patterns, as measured by diet quality scores, were associated with reduced risks of NTDs and clefts. These results suggest that dietary approaches could lead to further reduction in risks of major birth defects and complement existing efforts to fortify foods and encourage periconceptional multivitamin use.
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DOI：
10.1016/s0002-8223(98)00202-8
发表时间：
1998-08-01
影响因子：
--
作者：
Schaffer, DM;Velie, EM;Todoroff, KP
通讯作者：
Todoroff, KP
影响因子：
5
作者：
Cogswell, Mary E.;Bitsko, Rebecca H.;Reefhuis, Jennita
通讯作者：
Reefhuis, Jennita
影响因子：
--
作者：
Montez, Jennifer Karas;Eschbach, Karl
通讯作者：
Eschbach, Karl
影响因子：
4.7
作者：
Carmichael, SL;Shaw, GM;Schaffer, DM
通讯作者：
Schaffer, DM
影响因子：
105.7
作者：
LAURENCE, KM;JAMES, N;CAMPBELL, H
通讯作者：
CAMPBELL, H