Circulating circERBB2 as a potential prognostic biomarker for gastric cancer: An investigative study.
Circulating circERBB2 as a potential prognostic biomarker for gastric cancer: An investigative study.
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DOI：
10.1111/cas.14645
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发表时间：
2020-11
期刊：
影响因子：
5.7
通讯作者：
Otsuji E
中科院分区：
文献类型：
--
作者：
Nanishi K;Konishi H;Shoda K;Arita T;Kosuga T;Komatsu S;Shiozaki A;Kubota T;Fujiwara H;Okamoto K;Ichikawa D;Otsuji E
环状RNA是一种新型的内源性非编码RNA，由于其稳定的环结构，可以作为生物标志物。我们调查并检验了血浆circERBB2作为70例接受胃切除术的胃癌患者的预后生物标志物的效用。我们通过真实的实时定量PCR研究了术前和术后血浆中的circERBB 2浓度以及切除肿瘤中的circERBB 2表达。分析血浆circERBB 2浓度与临床病理特征及预后的关系。在37例患者的术前血浆样本中检测到circERBB2。术前血浆中circERBB2的存在（高水平组）与淋巴结转移显著相关（P = 0.035），并且倾向于与男性相关（P = 0.069）。高剂量组的无复发生存率和总生存率均显著较差（分别为P = .001和P = .009）。考克斯比例风险模型显示，高剂量组是无复发生存期的独立预后因素（P = 0.038）。高剂量组16例患者中，13例患者术后血浆中未显示circERBB 2。复发性癌症患者的血浆circERBB2浓度显著高于无复发患者（P < .001）。在2例复发性癌症患者中，血浆circERBB 2浓度升高，而在2例无复发患者中，这些浓度在治疗过程中几乎没有变化。术前血浆circERBB2浓度可作为胃癌无创性预后生物标志物。此外，监测术后血浆circERBB2浓度可能有助于检测胃癌复发。在胃癌患者中，术前血浆circERBB2水平高表明预后不良，复发时血浆circERBB2水平升高。血浆circERBB2可作为一种无创性的预后生物标志物，并可用于检测胃癌复发。
Circular RNA is a novel endogenous non‐coding RNA that can serve as a biomarker because of its stable loop structure. We investigated and examined the utility of plasma circERBB2 as a prognostic biomarker in 70 patients with gastric cancer who underwent gastrectomy. We investigated by real‐time quantitative PCR the circERBB2 concentrations in the preoperative and postoperative plasma and the circERBB2 expression in the resected tumors. The relationships between circERBB2 concentration in plasma and the clinicopathological features and prognosis were analyzed. circERBB2 was detected in the preoperative plasma samples of 37 patients. The presence of circERBB2 in preoperative plasma (high group) was significantly correlated with lymph node metastasis (P = .035) and tended to be correlated with men (P = .069). Both relapse‐free and overall survival were significantly poor in the high group (P = .001 and P = .009, respectively). The Cox proportional‐hazard model revealed that the high group was an independent prognostic factor of relapse‐free survival (P = .038). Among 16 patients of the high group, 13 patients did not show circERBB2 in the postoperative plasma. The concentration of circERBB2 in plasma was significantly higher in patients with recurrent cancer than those recurrence‐free patients (P < .001). In 2 patients with recurrent cancer, plasma circERBB2 concentrations were increased, whereas, in 2 recurrence‐free patients, these concentrations hardly changed during the treatment progress. The circERBB2 concentrations in preoperative plasma samples can be considered as a noninvasive prognostic biomarker for gastric cancer. Furthermore, monitoring the postoperative plasma circERBB2 concentrations may be useful for detecting gastric cancer recurrences. In patients with gastric cancer, high levels of preoperative plasma circERBB2 showed poor prognosis and the plasma level of circERBB2 increased at recurrence. Plasma circERBB2 can be a noninvasive prognostic biomarker and useful for the detection of gastric cancer recurrences.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
DOI：
10.1146/annurev.pathol.4.110807.092222
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
--
作者：
Lee YS;Dutta A
通讯作者：
Dutta A
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ
血清中 microRNA 的表征：一类用于诊断癌症和其他疾病的新型生物标志物
影响因子：
44.1
作者：
Chen, Xi;Ba, Yi;Zhang, Chen-Yu
通讯作者：
Zhang, Chen-Yu
DOI：
10.1016/j.bbrc.2019.03.010
发表时间：
2019-04-16
影响因子：
3.1
作者：
Li, Xuesong;He, Mu;Cao, Ting
通讯作者：
Cao, Ting