Association of discoid lupus erythematosus with other clinical manifestations among patients with systemic lupus erythematosus.
Association of discoid lupus erythematosus with other clinical manifestations among patients with systemic lupus erythematosus.
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DOI：
10.1016/j.jaad.2013.02.010
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发表时间：
2013-07
影响因子：
13.8
通讯作者：
Costenbader, Karen H.
中科院分区：
文献类型：
--
作者：
Merola, Joseph F.;Prystowsky, Stephen D.;Iversen, Christina;Gomez-Puerta, Jose A.;Norton, Tabatha;Tsao, Peter;Massarotti, Elena;Schur, Peter;Bermas, Bonnie;Costenbader, Karen H.
关键词：
SLE患者中的皮肤盘状狼疮（DLE）可能与较轻的疾病有关，肾炎和终末期肾病（ESRD）的发生率较低。研究确诊的DLE和其他SLE表现之间的关系，调整混杂因素。根据1997年ACR SLE分类标准，我们确定了经风湿病学家确认的患者，>2次访视，>3个月随访，并记录了SLE诊断的年份。DLE由皮肤科医生证实，并得到组织病理学和图像的支持。收集SLE表现、药物和血清学。多变量调整逻辑回归分析检测DLE与ACR SLE标准和ESRD之间的相关性。共有1，043名SLE患者（117名DLE患者和926名无DLE患者）被纳入研究。经多因素校正后，DLE与光敏性（OR 1.63）、白细胞减少（OR 1.55）和抗Smith抗体（OR 2.41）显著相关。DLE与关节炎（OR 0.49）和胸膜炎（OR 0.56）的风险降低显著相关。我们发现DLE与肾炎或终末期肾病之间无显著相关性。横断面数据收集，存在未从系统外访视中采集数据的风险。在我们的SLE队列中，DLE由皮肤科医生证实，我们调整了药物使用，特别是羟氯喹的可能混淆。我们发现SLE合并DLE患者的光敏性、白细胞减少和抗Smith抗体的风险增加，而胸膜炎和关节炎的风险降低。DLE与抗dsDNA抗体、狼疮性肾炎或终末期肾病无关。这些发现对SLE患者的预后有意义。
Cutaneous discoid lupus (DLE) among SLE patients may be associated with less severe disease, with low frequency of nephritis and end-stage renal disease (ESRD). To investigate associations between confirmed DLE and other SLE manifestations, adjusting for confounders. We identified patients with rheumatologist confirmation, according to ACR SLE classification criteria 1997, >2 visits, >3 months of follow-up, and documented year of SLE diagnosis. DLE was confirmed by dermatologist, supported by histopathology and images. SLE manifestations, medications and serologies were collected. Multivariable-adjusted logistic regression analyses tested for associations between DLE and each of the ACR SLE criteria, and ESRD. A total of 1,043 SLE patients, (117 with DLE and 926 without DLE), were included in the study. After multivariable adjustment, DLE in SLE was significantly associated with photosensitivity (OR 1.63), leukopenia (OR 1.55) and anti-Smith antibodies (OR 2.41). DLE was significantly associated with reduced risks of arthritis (OR 0.49) and pleuritis (OR 0.56). We found no significant associations between DLE and nephritis or ESRD. Cross-sectional data collection with risk of data not captured from visits outside system. In our SLE cohort, DLE was confirmed by a dermatologist and we adjusted for possible confounding by medication use, in particular hydroxychloroquine. We found increased risks of photosensitivity, leukopenia and anti-Smith antibodies and decreased risks of pleuritis and arthritis in SLE patients with DLE. DLE was not related to anti-dsDNA antibodies, lupus nephritis, or ESRD. These findings have implications for prognosis among SLE patients.
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影响因子：
4.7
作者：
Santiago-Casas, Yesenia;Vila, Luis M.;McGwin, Gerald, Jr.;Cantor, Ryan S.;Petri, Michelle;Ramsey-Goldman, Rosalind;Reveille, John D.;Kimberly, Robert P.;Alarcon, Graciela S.;Brown, Elizabeth E.
通讯作者：
Brown, Elizabeth E.
影响因子：
--
作者：
CALLEN, JP
通讯作者：
CALLEN, JP
影响因子：
27.4
作者：
Alba, P;Bento, L;Hughes, GRV
通讯作者：
Hughes, GRV
影响因子：
--
作者：
PRYSTOWSKY, SD;GILLIAM, JN
通讯作者：
GILLIAM, JN
DOI：
10.1016/s0190-9622(85)70217-4
发表时间：
1985-01-01
影响因子：
13.8
作者：
CALLEN, JP;FOWLER, JF;KULICK, KB
通讯作者：
KULICK, KB