Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohort.
Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohort.
复制标题
DOI：
10.1002/acr.21581
复制
发表时间：
2012-05
影响因子：
4.7
通讯作者：
Brown, Elizabeth E.
中科院分区：
文献类型：
--
作者：
Santiago-Casas, Yesenia;Vila, Luis M.;McGwin, Gerald, Jr.;Cantor, Ryan S.;Petri, Michelle;Ramsey-Goldman, Rosalind;Reveille, John D.;Kimberly, Robert P.;Alarcon, Graciela S.;Brown, Elizabeth E.
旨在确定大型多种族系统性红斑狼疮 (SLE) 队列中与盘状皮疹相关的临床表现和疾病损害。研究人员对来自纵向队列的 SLE 患者（根据 ACR 标准）、入组时年龄 ≥ 16 岁、病程 ≤ 10 年以及特定种族（非裔美国人、西班牙裔或白种人）进行了研究。确定了社会经济人口特征、临床表现和疾病损害[根据系统性狼疮国际合作诊所损害指数（SDI）]。使用多变量逻辑回归检查 DLE 与临床表现和疾病损害的关联。总共有 2,228 名 SLE 患者接受了研究。诊断时的平均（标准差，SD）年龄为 34.3（12.8）岁，平均（SD）病程为 7.9（6.0）年； 91.8%是女性。 393 名 (17.6%) 的 SLE 患者观察到盘状狼疮。在多变量分析中，盘状狼疮患者更有可能是吸烟者和非裔美国人，并且有颧骨皮疹、光过敏、口腔溃疡、白细胞减少和血管炎。 DLE 患者不太可能是西班牙裔（来自德克萨斯州），也不太可能患有关节炎、终末期肾病 (ESRD) 以及抗核、抗 dsDNA 和抗磷脂抗体。 DLE 患者会遭受更多损害，特别是慢性癫痫、疤痕性脱发、皮肤疤痕和皮肤溃疡。在这组 SLE 患者中，盘状狼疮与多种临床特征相关，包括血管炎和慢性癫痫等严重表现。
To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort. SLE patients (per ACR criteria), age ≥ 16 years, disease duration ≤ 10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal cohort were studied. Socioeconomic-demographic features, clinical manifestations and disease damage [as per the Systemic Lupus International Collaborating Clinics Damage Index (SDI)] were determined. The association of DLE with clinical manifestations and disease damage was examined using multivariable logistic regression. A total of 2,228 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.3 (12.8) years and the mean (SD) disease duration was 7.9 (6.0) years; 91.8% were women. Discoid lupus was observed in 393 (17.6%) of patients with SLE. In the multivariable analysis, patients with discoid lupus were more likely to be smokers and of African-American ethnicity, and to have malar rash, photosensitivity, oral ulcers, leukopenia and vasculitis. DLE patients were less likely to be of Hispanic (from Texas) ethnicity, and to have arthritis, end-stage renal disease (ESRD), and antinuclear, anti-dsDNA and anti-phospholipid antibodies. Patients with DLE had more damage accrual, particularly chronic seizures, scarring alopecia, scarring of the skin, and skin ulcers. In this cohort of SLE patients, discoid lupus was associated with several clinical features including serious manifestations such as vasculitis and chronic seizures.
登录
查看更多内容
影响因子：
27.4
作者：
Alarcon, Graciela S.;McGwin, Gerald;Reveille, John D.
通讯作者：
Reveille, John D.
影响因子：
15.3
作者：
IZUI, S;LAMBERT, PH;MIESCHER, PA
通讯作者：
MIESCHER, PA
DOI：
10.1016/s0190-9622(00)90290-1
发表时间：
2000-06-01
影响因子：
13.8
作者：
Jewell, ML;McCauliffe, DP
通讯作者：
McCauliffe, DP
影响因子：
4.1
作者：
Lopez-Tello, A.;Rodriguez-Carreon, A. A.;Granados, J.
通讯作者：
Granados, J.
影响因子：
2.6
作者：
Drenkard, C;Villa, AR;AlarconSegovia, D
通讯作者：
AlarconSegovia, D