Functional network organization of the human brain.

Functional network organization of the human brain.
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DOI:
10.1016/j.neuron.2011.09.006
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发表时间:
2011-11-17
期刊:
影响因子:
16.2
通讯作者:
Petersen SE
Petersen SE
中科院分区:
医学1区
文献类型:
--
作者:
Power JD;Cohen AL;Nelson SM;Wig GS;Barnes KA;Church JA;Vogel AC;Laumann TO;Miezin FM;Schlaggar BL;Petersen SE

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现实世界的复杂系统可以数学建模为图形,揭示系统的属性。在这里,我们研究了健康成年人使用静息状态功能连接MRI的功能脑组织图。我们提出了两个新的全脑图,一个是264个假定的功能区域,另一个是体素网络的修改,消除了潜在的人工短距离关系。这些图包含许多子图,与已知的脑功能系统非常一致。其他子图缺乏既定的功能标识,我们建议这些子图可能的功能特性。此外,区域网络的图形测量表明,默认模式子图与感觉和运动子图共享网络属性:它是内部集成的,但与其他子图隔离,很像一个“处理”系统。修改后的体素图还揭示了在整个皮层的系统模式的空间图案。
Real-world complex systems may be mathematically modeled as graphs, revealing properties of the system. Here we study graphs of functional brain organization in healthy adults using resting state functional connectivity MRI. We propose two novel brain-wide graphs, one of 264 putative functional areas, the other a modification of voxelwise networks that eliminates potentially artificial short-distance relationships. These graphs contain many subgraphs in good agreement with known functional brain systems. Other subgraphs lack established functional identities; we suggest possible functional characteristics for these subgraphs. Further, graph measures of the areal network indicate that the default mode subgraph shares network properties with sensory and motor subgraphs: it is internally integrated but isolated from other subgraphs, much like a “processing” system. The modified voxelwise graph also reveals spatial motifs in the patterning of systems across the cortex.
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