Cytochrome P450 enzymes in the brain: emerging evidence of biological significance.
Cytochrome P450 enzymes in the brain: emerging evidence of biological significance.
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DOI：
10.1016/j.tips.2011.08.005
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发表时间：
2011-12
影响因子：
13.8
通讯作者：
Tyndale RF
中科院分区：
文献类型：
--
作者：
Ferguson CS;Tyndale RF
细胞色素P450(Cyps)酶负责许多外源和内源化合物的代谢。CYPS在肝脏中含量丰富，在包括脑在内的许多肝外组织中也有表达。虽然大脑中的总CYP水平远低于肝脏，但大脑中的CYP集中在特定区域和细胞类型的药物靶点附近，可能会对局部代谢产生相当大的影响。由于诱导剂、抑制剂或基因变异，大脑CYP代谢的个体差异会影响对中枢作用药物的敏感性和反应。脑内细胞色素P450还可能在调节大脑活动、行为、对中枢神经系统疾病的易感性和治疗结果方面发挥作用。这篇综述着重介绍了在了解细胞色素P450在大脑中的功能意义方面取得的最新进展。
Cytochrome P450 (CYPs) enzymes are responsible for the metabolism of many exogenous and endogenous compounds. CYPs are abundant in the liver and are also expressed in many extra-hepatic tissues including the brain. Although the total CYP levels in the brain are much lower than in the liver, brain CYPs are concentrated near drug targets in specific regions and cell types, potentially having a considerable impact on local metabolism. Individual differences in brain CYP metabolism, due to inducers, inhibitors or genetic variation, can influence sensitivity and response to centrally acting drugs. Brain CYPs may also play a role in modulating brain activity, behavior, susceptibility to CNS diseases and treatment outcomes. This review highlights the recent progress that has been made in understanding the functional significance of CYPs in the brain.
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