Dynamic Changes in Central and Peripheral Neuro-Injury vs. Neuroprotective Serum Markers in COVID-19 Are Modulated by Different Types of Anti-Viral Treatments but Do Not Affect the Incidence of Late and Early Strokes.
Dynamic Changes in Central and Peripheral Neuro-Injury vs. Neuroprotective Serum Markers in COVID-19 Are Modulated by Different Types of Anti-Viral Treatments but Do Not Affect the Incidence of Late and Early Strokes.
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DOI：
10.3390/biomedicines9121791
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发表时间：
2021-11-29
期刊：
影响因子：
4.7
通讯作者：
Rader DJ
中科院分区：
文献类型：
--
作者：
Laudanski K;Hajj J;Restrepo M;Siddiq K;Okeke T;Rader DJ
神经退行性变、神经炎症、神经保护和新冠肺炎导向治疗之间的平衡可能是导致SARS-CoV-2‘S神经学结果异质性的根本原因。总共10 5名确诊为新冠肺炎的住院患者在6个月的时间里收集了血清，以评估神经炎性(MIF，CCL23，单核细胞趋化蛋白-1)、神经损伤(NFL，NCAM-1)、神经退行性变(KLK6，τ，磷酸化τ，淀粉样蛋白，TDP43，YKL40)和神经保护性(聚集素，胎蛋白，TREM-2)蛋白。将这些指标与非特异性炎症反应的标记物(IL-6、D-二聚体、C反应蛋白)和总的病毒负荷(刺激性蛋白)进行比较。收集有关治疗(类固醇、恢复期血浆、瑞达沙韦)、既往疾病和中风发生率的数据。淀粉样蛋白β42、TDP43、核因子-L和KLK6血清水平在入院后2-3天下降，但在入院7天恢复到入院基线水平。随着时间的推移，YKL-40和NCAM-1的水平仍然较高，在TREM-2、TDP43和YKL40之间发现了差异反应簇。胎球蛋白在新冠肺炎发病后升高，而TREM-2最初下降，然后随着时间的推移显着上升。入院后3~7d血清MIF水平升高。铁蛋白与TDP-43和KLK6相关。雷米地韦的治疗没有与淀粉样蛋白-β40的升高同时发生。缺乏恢复期血浆导致NCAM-1和总tau增加，类固醇治疗不会显著影响任何标志物。在新冠肺炎首次入院后6个月内，共有11例中风事件登记在案。观察到D-二聚体、血小板计数、IL-6和白细胞减少症。在新冠肺炎急性期，可变的MIF血清水平区分了咳嗽变异性哮喘患者和那些没有中风的患者。这项研究表明，神经退行性和神经保护性标记物的相伴和相反的变化一直持续到康复。
The balance between neurodegeneration, neuroinflammation, neuroprotection, and COVID-19-directed therapy may underly the heterogeneity of SARS-CoV-2′s neurological outcomes. A total of 105 patients hospitalized with a diagnosis of COVID-19 had serum collected over a 6 month period to assess neuroinflammatory (MIF, CCL23, MCP-1), neuro-injury (NFL, NCAM-1), neurodegenerative (KLK6, τ, phospho τ, amyloids, TDP43, YKL40), and neuroprotective (clusterin, fetuin, TREM-2) proteins. These were compared to markers of nonspecific inflammatory responses (IL-6, D-dimer, CRP) and of the overall viral burden (spike protein). Data regarding treatment (steroids, convalescent plasma, remdasavir), pre-existing conditions, and incidences of strokes were collected. Amyloid β42, TDP43, NF-L, and KLK6 serum levels declined 2–3 days post-admission, yet recovered to admission baseline levels by 7 days. YKL-40 and NCAM-1 levels remained elevated over time, with clusters of differential responses identified among TREM-2, TDP43, and YKL40. Fetuin was elevated after the onset of COVID-19 while TREM-2 initially declined before significantly increasing over time. MIF serum level was increased 3–7 days after admission. Ferritin correlated with TDP-43 and KLK6. No treatment with remdesivir coincided with elevations in Amyloid-β40. A lack of convalescent plasma resulted in increased NCAM-1 and total tau, and steroidal treatments did not significantly affect any markers. A total of 11 incidences of stroke were registered up to six months after initial admission for COVID-19. Elevated D-dimer, platelet counts, IL-6, and leukopenia were observed. Variable MIF serum levels differentiated patients with CVA from those who did not have a stroke during the acute phase of COVID-19. This study demonstrated concomitant and opposite changes in neurodegenerative and neuroprotective markers persisting well into recovery.
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IP-10 和 MCP-1 作为与 COVID-19 疾病严重程度相关的生物标志物。
DOI：
10.1186/s10020-020-00230-x
发表时间：
2020-10-29
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Chen Y;Wang J;Liu C;Su L;Zhang D;Fan J;Yang Y;Xiao M;Xie J;Xu Y;Li Y;Zhang S
通讯作者：
Zhang S
影响因子：
3.7
作者：
Blennow K
通讯作者：
Blennow K
YKL-40：一种用于临床前阿尔茨海默病的新型预后液体生物标志物。
影响因子：
10.6
作者：
Craig-Schapiro, Rebecca;Perrin, Richard J.;Roe, Catherine M.;Xiong, Chengjie;Carter, Deborah;Cairns, Nigel J.;Mintun, Mark A.;Peskind, Elaine R.;Li, Ge;Galasko, Douglas R.;Clark, Christopher M.;Quinn, Joseph F.;D'Angelo, Gina;Malone, James P.;Townsend, R. Reid;Morris, John C.;Fagan, Anne M.;Holtzman, David M.
通讯作者：
Holtzman, David M.
DOI：
10.1136/jnnp-2020-322983
发表时间：
2020-11-11
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
de Boer EMJ;Orie VK;Williams T;Baker MR;De Oliveira HM;Polvikoski T;Silsby M;Menon P;van den Bos M;Halliday GM;van den Berg LH;Van Den Bosch L;van Damme P;Kiernan MC;van Es MA;Vucic S
通讯作者：
Vucic S
影响因子：
6
作者：
De Lorenzo R;Loré NI;Finardi A;Mandelli A;Cirillo DM;Tresoldi C;Benedetti F;Ciceri F;Rovere-Querini P;Comi G;Filippi M;Manfredi AA;Furlan R
通讯作者：
Furlan R