Variation, evolution, and correlation analysis of C+G content and genome or chromosome size in different kingdoms and phyla.
Variation, evolution, and correlation analysis of C+G content and genome or chromosome size in different kingdoms and phyla.
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DOI：
10.1371/journal.pone.0088339
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Du D
中科院分区：
文献类型：
--
作者：
Li XQ;Du D
已知细菌中C+G含量（GC含量或G+C含量）与基因组/染色体大小相关，但其他领域的关系尚不清楚。本研究分析了不同物种中大多数已测序基因组的基因组大小、染色体大小和碱基组成。在植物和动物的进化过程中，基因组的大小往往会增加，细菌可能也是如此。基因组C+G含量在微生物中差异很大，但在每个动物或植物亚界中非常相似。在动物和植物中，C+G含量的排序为：单子叶植物>哺乳动物>非哺乳动物>双子叶植物。物种内C+G含量的差异在动物中比在植物中更大。在变形菌门、放线菌门和子囊菌门真菌中，平均染色体C+G含量与染色体长度呈显著正相关，在某些植物中也可能呈显著正相关；在一些动物中呈阴性，在两个原生门中不明显，在古细菌中可能很弱。显然，C+G含量与染色体大小之间的相关性可能是正的，负的，或不显著取决于王国/群体或物种。不同的门或种在染色体大小与C+G含量之间表现出不同的相关模式。一个物种内的大多数染色体在C+G含量上具有相似的变异模式，但异常值是常见的。本研究结果表明，C+G含量受反式因子和顺式因子的遗传控制，在不同门中，C+G含量与染色体长度的相关性可为正相关、负相关或不显著相关。
C+G content (GC content or G+C content) is known to be correlated with genome/chromosome size in bacteria but the relationship for other kingdoms remains unclear. This study analyzed genome size, chromosome size, and base composition in most of the available sequenced genomes in various kingdoms. Genome size tends to increase during evolution in plants and animals, and the same is likely true for bacteria. The genomic C+G contents were found to vary greatly in microorganisms but were quite similar within each animal or plant subkingdom. In animals and plants, the C+G contents are ranked as follows: monocot plants>mammals>non-mammalian animals>dicot plants. The variation in C+G content between chromosomes within species is greater in animals than in plants. The correlation between average chromosome C+G content and chromosome length was found to be positive in Proteobacteria, Actinobacteria (but not in other analyzed bacterial phyla), Ascomycota fungi, and likely also in some plants; negative in some animals, insignificant in two protist phyla, and likely very weak in Archaea. Clearly, correlations between C+G content and chromosome size can be positive, negative, or not significant depending on the kingdoms/groups or species. Different phyla or species exhibit different patterns of correlation between chromosome-size and C+G content. Most chromosomes within a species have a similar pattern of variation in C+G content but outliers are common. The data presented in this study suggest that the C+G content is under genetic control by both trans- and cis- factors and that the correlation between C+G content and chromosome length can be positive, negative, or not significant in different phyla.
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影响因子：
4.6
作者：
Li, Xiu-Qing;Du, Donglei
通讯作者：
Du, Donglei
影响因子：
3.9
作者：
Halaimia-Toumi, N;Casse, N;Laulier, M
通讯作者：
Laulier, M
DOI：
10.1073/pnas.0610585104
发表时间：
2007-01-23
影响因子：
11.1
作者：
Chabes, Andrei;Stillman, Bruce
通讯作者：
Stillman, Bruce
影响因子：
4.2
作者：
Cullis, CA
通讯作者：
Cullis, CA
影响因子：
3.7
作者：
Li XQ;Du D
通讯作者：
Du D