Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons.
Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons.
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DOI：
10.1038/ejcn.2011.203
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发表时间：
2012-05
影响因子：
4.7
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中科院分区：
文献类型：
--
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在对小鼠进行的研究中，玫瑰果粉已被证明可以预防和逆转高脂肪饮食引起的肥胖和葡萄糖耐受不良，以及降低血浆胆固醇水平。本研究的目的是调查每天摄入玫瑰果粉超过6周是否对肥胖个体产生有益的代谢作用。共有31名葡萄糖耐量正常或受损的肥胖个体参加了一项随机、双盲、交叉研究，其中每日摄入玫瑰果粉饮料6周以上的代谢效果与对照饮料进行了比较。对受试者的体重、葡萄糖耐量、血压、血脂和炎症标志物进行评估。与对照饮料相比，每天饮用6周的玫瑰果饮料导致收缩压（-3.4%P =0.021），总血浆胆固醇（-4.9%P =0.0018），低密度脂蛋白（LDL）胆固醇（-6.0%P =0.012）和LDL/HDL比率（-6.5%P =0.041）显着降低。与对照组相比，玫瑰果组的心血管疾病Reynolds风险评估评分降低（-17%P =0.007）。体重、舒张压、葡萄糖耐量、高密度脂蛋白胆固醇、甘油三酯、肠促胰岛素和炎症标志物的血浆水平在两组之间没有差异。每天食用40克玫瑰果粉6周，可通过降低收缩压和血浆胆固醇水平，显著降低肥胖人群的心血管风险。
In studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol. The aim of this study was to investigate whether daily intake of rose hip powder over 6 weeks exerts beneficial metabolic effects in obese individuals. A total of 31 obese individuals with normal or impaired glucose tolerance were enrolled in a randomized, double-blind, cross-over study in which metabolic effects of daily intake of a rose hip powder drink over 6 weeks was compared with a control drink. Body weight, glucose tolerance, blood pressure, blood lipids and markers of inflammation were assessed in the subjects. In comparison with the control drink, 6 weeks of daily consumption of the rose hip drink resulted in a significant reduction of systolic blood pressure (−3.4% P=0.021), total plasma cholesterol (−4.9% P=0.0018), low-density lipoprotein (LDL) cholesterol (−6.0% P=0.012) and LDL/HDL ratio (−6.5% P=0.041). The Reynolds risk assessment score for cardiovascular disease was decreased in the rose hip group compared with the control group (−17% P=0.007). Body weight, diastolic blood pressure, glucose tolerance, and plasma levels of high-density lipoprotein (HDL) cholesterol, triglycerides, incretins and markers of inflammation did not differ between the two groups. Daily consumption of 40 g of rose hip powder for 6 weeks can significantly reduce cardiovascular risk in obese people through lowering of systolic blood pressure and plasma cholesterol levels.
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影响因子：
168.9
作者：
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通讯作者：
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