Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.
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DOI：
10.1016/j.semcdb.2010.01.017
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发表时间：
2010-05
影响因子：
7.3
通讯作者：
Hinchcliffe EH
中科院分区：
文献类型：
--
作者：
Hornick JE;Karanjeet K;Collins ES;Hinchcliffe EH
在哺乳动物培养的细胞中，细胞分裂的起始是由纺锤体中部重叠的、反平行的微管在时间和空间上调控的。该区域招募了几个关键的中央纺锤体成分：PRC-1， polo样激酶1 (Plk-1)，中央纺锤体复合体和染色体客运复合体（CPC），它们共同稳定微管重叠，并协调皮质肌动蛋白/肌球蛋白细胞骨架的组装，这是将细胞物理切割为两部分所必需的。将这些关键元件定位到纺锤体中间区需要基于微管的运动蛋白的运动蛋白超家族成员。在这里，我们重点回顾了在细胞分裂过程中，各种驱动蛋白在纺锤体中间区机制的建立和运作中所起的作用。
In mammalian cultured cells the initiation of cytokinesis is regulated – both temporally and spatially – by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, Polo-like kinase 1 (Plk-1), the centralspindlin complex, and the Chromosome Passenger Complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.
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影响因子：
21.3
作者：
Bakhoum, Samuel F.;Thompson, Sarah L.;Manning, Amity L.;Compton, Duane A.
通讯作者：
Compton, Duane A.
影响因子：
4.8
作者：
Ban, R;Irino, Y;Tanaka, H
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Tanaka, H
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19
作者：
Adams, RR;Carmena, M;Earnshaw, WC
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Earnshaw, WC
影响因子：
64.8
作者：
Canman, JC;Cameron, LA;Salmon, ED
通讯作者：
Salmon, ED
影响因子：
9.8
作者：
Burkard ME;Maciejowski J;Rodriguez-Bravo V;Repka M;Lowery DM;Clauser KR;Zhang C;Shokat KM;Carr SA;Yaffe MB;Jallepalli PV
通讯作者：
Jallepalli PV