Gamma-Band Oscillations Preferential for Nociception can be Recorded in the Human Insula.
Gamma-Band Oscillations Preferential for Nociception can be Recorded in the Human Insula.
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DOI：
10.1093/cercor/bhx237
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发表时间：
2018-10-01
期刊：
影响因子：
--
通讯作者：
Mouraux A
中科院分区：
文献类型：
--
作者：
Liberati G;Klöcker A;Algoet M;Mulders D;Maia Safronova M;Ferrao Santos S;Ribeiro Vaz JG;Raftopoulos C;Mouraux A
短暂的伤害性刺激在人的脑干中引起稳定的锁相局部场电位（LFPs）。然而，这些反应并不优先于伤害性感受，因为它们也由瞬时非伤害性振动触觉、听觉和视觉刺激引起。在这里，我们调查是否岛活动的另一个功能，即γ-波段振荡（GBO），优先观察到的伤害性刺激。虽然伤害性刺激诱发的GBO从来没有被探索过，头皮脑电图和脑磁图研究表明，伤害性刺激引起GBO在其他领域，如初级躯体感觉和前额叶皮层，这种活动可能与疼痛感知密切相关。此外，追踪研究表明，丘脑是脊髓丘脑输入的主要目标。使用深度电极植入9例癫痫患者进行调查，我们获得了短暂的thermociceptive刺激，同样引起非伤害性振动触觉，听觉和视觉刺激（59岛网站）的岛屿反应。与非伤害性刺激相比，伤害性刺激在所有岛叶部位引起GBO的明显更强的增强（刺激后150-300 ms），这表明岛叶活动的这种特征对于热感受是优先的。虽然这种活动也存在于颞叶和额叶区域，但与其他区域相比，其幅度在海马区明显更大。
Transient nociceptive stimuli elicit robust phase-locked local field potentials (LFPs) in the human insula. However, these responses are not preferential for nociception, as they are also elicited by transient non-nociceptive vibrotactile, auditory, and visual stimuli. Here, we investigated whether another feature of insular activity, namely gamma-band oscillations (GBOs), is preferentially observed in response to nociceptive stimuli. Although nociception-evoked GBOs have never been explored in the insula, previous scalp electroencephalography and magnetoencephalography studies suggest that nociceptive stimuli elicit GBOs in other areas such as the primary somatosensory and prefrontal cortices, and that this activity could be closely related to pain perception. Furthermore, tracing studies showed that the insula is a primary target of spinothalamic input. Using depth electrodes implanted in nine patients investigated for epilepsy, we acquired insular responses to brief thermonociceptive stimuli and similarly arousing non-nociceptive vibrotactile, auditory, and visual stimuli (59 insular sites). As compared to non-nociceptive stimuli, nociceptive stimuli elicited a markedly stronger enhancement of GBOs (150-300 ms post-stimulus) at all insular sites, suggesting that this feature of insular activity is preferential for thermonociception. Although this activity was also present in temporal and frontal regions, its magnitude was significantly greater in the insula as compared to these other regions.
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影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
4.8
作者：
Cerliani, Leonardo;Thomas, Rajat M.;Jbabdi, Saad;Siero, Jeroen C. W.;Nanetti, Luca;Crippa, Alessandro;Gazzola, Valeria;D'Arceuil, Helen;Keysers, Christian
通讯作者：
Keysers, Christian
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
DOI：
10.1523/jneurosci.1457-11.2011
发表时间：
2011-09-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Conner CR;Ellmore TM;Pieters TA;DiSano MA;Tandon N
通讯作者：
Tandon N
影响因子：
2.5
作者：
Davis, KD;Kwan, CL;Mikulis, DJ
通讯作者：
Mikulis, DJ