Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex.
Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex.
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DOI：
10.1002/hbm.21338
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发表时间：
2012-09
影响因子：
4.8
通讯作者：
Keysers, Christian
中科院分区：
文献类型：
--
作者：
Cerliani, Leonardo;Thomas, Rajat M.;Jbabdi, Saad;Siero, Jeroen C. W.;Nanetti, Luca;Crippa, Alessandro;Gazzola, Valeria;D'Arceuil, Helen;Keysers, Christian
猕猴的岛叶皮质具有广泛的解剖连接，其分布与其异质性细胞结构相关。虽然有证据表明，在人类中有一个类似的细胞结构的安排，在人脑中的神经元的解剖连接尚未在体内研究。在目前的工作中，我们使用体内概率性白色-物质纤维束成像和拉普拉斯特征图（LE）来研究人类岛状领土之间的连接模式的变化。在每个主题和半球，我们恢复了rostrocaudal轨迹的连接变化范围从前背侧和腹侧的长岛回的背侧尾侧部分。LE认为，在小脑的纤维束成像模式之间的区域转换比其他脑区发生得更缓慢。特别是，纤维束成像模式的变化在延髓比在内侧运动前区更为平缓，在内侧运动前区，发现不同纤维束成像模式之间的急剧过渡。恢复的延髓连接变化轨迹表明，人类的连接和细胞结构之间的关系类似于以前在猕猴中发现的关系：来自前额叶的纤维束种子主要分布在边缘区、边缘区和额下回前部，而来自尾侧岛区的种子主要到达顶叶和后颞叶皮质。在假定的dysgranular的区域显示更多的异质性连接模式，与区域差异有关的接近无论是假定的颗粒或agranular区域。《脑图谱》33：2005 - 2034，2012年。© 2011 Wiley Periodicals，Inc.
The insular cortex of macaques has a wide spectrum of anatomical connections whose distribution is related to its heterogeneous cytoarchitecture. Although there is evidence of a similar cytoarchitectural arrangement in humans, the anatomical connectivity of the insula in the human brain has not yet been investigated in vivo. In the present work, we used in vivo probabilistic white‐matter tractography and Laplacian eigenmaps (LE) to study the variation of connectivity patterns across insular territories in humans. In each subject and hemisphere, we recovered a rostrocaudal trajectory of connectivity variation ranging from the anterior dorsal and ventral insula to the dorsal caudal part of the long insular gyri. LE suggested that regional transitions among tractography patterns in the insula occur more gradually than in other brain regions. In particular, the change in tractography patterns was more gradual in the insula than in the medial premotor region, where a sharp transition between different tractography patterns was found. The recovered trajectory of connectivity variation in the insula suggests a relation between connectivity and cytoarchitecture in humans resembling that previously found in macaques: tractography seeds from the anterior insula were mainly found in limbic and paralimbic regions and in anterior parts of the inferior frontal gyrus, while seeds from caudal insular territories mostly reached parietal and posterior temporal cortices. Regions in the putative dysgranular insula displayed more heterogeneous connectivity patterns, with regional differences related to the proximity with either putative granular or agranular regions. Hum Brain Mapp 33:2005–2034, 2012. © 2011 Wiley Periodicals, Inc.
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