Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
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翻转代谢开关：了解和应用禁食的健康益处。
DOI：
10.1002/oby.22065
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Mattson MP
中科院分区：
文献类型：
--
作者：
Anton SD;Moehl K;Donahoo WT;Marosi K;Lee SA;Mainous AG 3rd;Leeuwenburgh C;Mattson MP
间歇性禁食（IF）是一个术语，用于描述各种饮食模式，其中不消耗或消耗很少的卡路里，持续时间从12小时到几天不等。在这里，我们专注于主要器官系统的生理反应，包括肌肉骨骼系统，代谢转换的开始-负能量平衡点，在此点上肝糖原储备耗尽，脂肪酸被动员（通常超过12小时后停止进食）。新的发现表明，从葡萄糖到脂肪酸衍生的酮的代谢转换代表了进化上保守的触发点，其将代谢从脂质/胆固醇合成和脂肪储存转移到通过脂肪酸氧化和脂肪酸衍生的酮动员脂肪，这有助于保持肌肉质量和功能。因此，诱导代谢转换的IF方案有可能改善超重个体的身体组成。此外，IF方案还诱导信号通路的协调激活，优化生理功能，提高性能，减缓衰老和疾病过程。未来的随机对照IF试验应使用代谢转换的生物标志物（例如，血浆酮水平）作为禁食期间的顺应性和负能量平衡的大小的量度。
Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. Here we focus on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch – the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). Emerging findings suggest the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty-acid derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and the magnitude of negative energy balance during the fasting period.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
DOI：
10.1016/j.bbalip.2015.01.013
发表时间：
2015-05-01
影响因子：
4.8
作者：
Baumeier, Christian;Kaiser, Daniel;Schuermann, Annette
通讯作者：
Schuermann, Annette
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
影响因子：
5.4
作者：
Belkacemi, Louiza;Selselet-Attou, Ghalem;Malaisse, Willy J.
通讯作者：
Malaisse, Willy J.
影响因子：
3.2
作者：
De Vynck, Jan C.;Anderson, Robert;Hill, Kim
通讯作者：
Hill, Kim