Toxicokinetics, dose-response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives.
Toxicokinetics, dose-response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives.
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DOI：
10.1002/wnan.1808
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发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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纳米材料应用的快速增长引发了对人类健康的安全担忧。已经进行了许多研究，使用体外和体内动物和人类模型评估不同纳米材料的毒代动力学、毒理学、剂量反应和风险评估。然而，目前的研究不能满足有效评估毒理学、剂量-反应关系的需求，也不能满足快速增加的新合成纳米材料数量所产生的毒理学风险的需求。在这篇文章中，我们回顾了纳米材料的毒理学、危害识别、剂量反应、暴露和风险评估研究的方法，确定了知识差距，并讨论了仍然存在的挑战。我们提供了纳米材料血浆毒代动力学和组织分布研究的适当设计背后的基本原理，包括体外和体内毒理学研究的解释和相关性的警告。讨论了使用基于生理学的药代动力学（PBPK）模型从体外到体内以及从动物到人类推断毒代动力学和毒性结果的潜力，并确定了纳米材料PBPK建模的知识差距。尽管挑战依然存在，但过去二十年来，在纳米材料的毒理学、危害识别和风险评估方面取得了进展。该领域的最新进展突出了相关的例子。我们还分享了最新的指南以及我们对未来研究的看法，这些研究需要表征毒理学，毒性和剂量-反应关系，以支持纳米材料风险评估。本文总结了纳米材料的毒理学、危害识别、剂量-反应、暴露和风险评估研究方法，确定了知识差距，讨论了主要挑战，并分享了最新指南和我们对未来研究的看法。
The rapid growth of nanomaterial applications has raised safety concerns for human health. A number of studies have been conducted to assess the toxicokinetics, toxicology, dose-response, and risk assessment of different nanomaterials using in vitro and in vivo animal and human models. However, current studies cannot meet the demand for efficient assessment of toxicokinetics, dose-response relationships nor the toxicological risk arising from the rapidly increasing number of newly synthesized nanomaterials. In this article, we review the methods for conducting toxicokinetics, hazard identification, dose-response, exposure and risk assessment studies of nanomaterials, identify the knowledge gaps, and discuss the challenges remaining. We provide the rationale behind the appropriate design of nanomaterial plasma toxicokinetic and tissue distribution studies, including caveats on the interpretation and correlation of in vitro and in vivo toxicology studies. The potential of using physiologically based pharmacokinetic (PBPK) models to extrapolate toxicokinetic and toxicity findings from in vitro to in vivo and from animals to humans is discussed, and the knowledge gaps of PBPK modeling for nanomaterials are identified. While challenges still exist, there has been progress in the toxicokinetics, hazard identification, and risk assessment of nanomaterials in the past two decades. Recent advancements in the field are highlighted with relevant examples. We also share latest guidelines as well as our perspectives on future studies needed to characterize the toxicokinetics, toxicity, and dose-response relationship in support of nanomaterial risk assessment. This article summarizes the methods for toxicokinetics, hazard identification, dose-response, exposure and risk assessment studies of nanomaterials, identifies the knowledge gaps, discusses the main challenges, and shares the latest guidelines and our perspectives on future studies.
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影响因子：
8
作者：
Badrigilan S;Heydarpanahi F;Choupani J;Jaymand M;Samadian H;Hoseini-Ghahfarokhi M;Webster TJ;Tayebi L
通讯作者：
Tayebi L
影响因子：
5
作者：
Bachler, Gerald;von Goetz, Natalie;Hungerbuhler, Konrad
通讯作者：
Hungerbuhler, Konrad
影响因子：
5.3
作者：
Aureli, Federica;Ciprotti, Maria;Cubadda, Francesco
通讯作者：
Cubadda, Francesco
DOI：
10.1002/smll.201603847
发表时间：
2017-04
期刊：
Small (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
Chinen AB;Guan CM;Ko CH;Mirkin CA
通讯作者：
Mirkin CA
DOI：
10.1073/pnas.1103573108
发表时间：
2011-04-19
影响因子：
11.1
作者：
Choi, Chung Hang J.;Zuckerman, Jonathan E.;Davis, Mark E.
通讯作者：
Davis, Mark E.