Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood.
Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood.
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DOI：
10.3389/fnbeh.2014.00073
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发表时间：
2014
影响因子：
3
通讯作者：
Bhatnagar S
中科院分区：
文献类型：
--
作者：
Hsu DT;Kirouac GJ;Zubieta JK;Bhatnagar S
本文综述了丘脑室旁核的功能和联系在应激和负性情绪行为调节中的作用。Pa位于丘脑背中线，受到血清素、去甲肾上腺素、多巴胺（DA）、促肾上腺皮质激素释放激素和食欲素（ORX）的严重神经支配，并且是唯一与杏仁核、终纹床核等结构相连的丘脑核（BNST）、伏核（NAcc）和边缘下/膝下前扣带回皮质（sgACC）。这些神经递质系统和结构参与调节动机和情绪，并在几种精神疾病中显示出异常功能，包括焦虑，物质使用和重度抑郁症（MDD）。此外，啮齿类动物的研究表明，Pa是一致的，并在各种压力刺激后有效激活，并在调节慢性应激反应中具有独特的作用。这些观察结果提供了一个令人信服的理由调查压力和消极的情绪行为之间的联系，并包括压力相关的精神疾病的神经通路的Pa。
The purpose of this review is to describe how the function and connections of the paraventricular thalamic nucleus (Pa) may play a role in the regulation of stress and negative emotional behavior. Located in the dorsal midline thalamus, the Pa is heavily innervated by serotonin, norepinephrine, dopamine (DA), corticotropin-releasing hormone, and orexins (ORX), and is the only thalamic nucleus connected to the group of structures comprising the amygdala, bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAcc), and infralimbic/subgenual anterior cingulate cortex (sgACC). These neurotransmitter systems and structures are involved in regulating motivation and mood, and display abnormal functioning in several psychiatric disorders including anxiety, substance use, and major depressive disorders (MDD). Furthermore, rodent studies show that the Pa is consistently and potently activated following a variety of stressors and has a unique role in regulating responses to chronic stressors. These observations provide a compelling rationale for investigating the Pa in the link between stress and negative emotional behavior, and for including the Pa in the neural pathways of stress-related psychiatric disorders.
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DOI：
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