Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse.
Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse.
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拼命驱动，没有刹车：发育压力暴露和随后滥用毒品的风险。
DOI：
10.1016/j.neubiorev.2008.09.009
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发表时间：
2009-04
影响因子：
8.2
通讯作者：
Teicher, Martin H.
中科院分区：
文献类型：
--
作者：
Andersen, Susan L.;Teicher, Martin H.
ANDERSEN，S.L.和TEICHER，M.H.绝望的驾驶和没有刹车：发育压力暴露和随后的药物滥用风险。NEUROSCI BIOSDE V版本XX（X）XXX-XXX，2008年。不良生活事件与广泛的精神病理学相关，包括药物滥用风险增加。在这篇评论中，我们重点关注逆境与大脑发育之间的相互关系，并将其与增强的脆弱性窗口联系起来。这篇综述包括临床和临床前数据，从流行病学研究、形态测量和功能成像研究以及分子生物学和遗传学中汲取证据。敏感时期的接触与成熟期事件的相互作用产生了级联效应，导致在较年轻时开始使用药物，并增加了在青春期或成年早期成瘾的可能性。压力孵化/皮质边缘功能障碍模型提出的基础上的相互作用的压力暴露，发展阶段，和神经成熟的事件，可以解释寻求特定类别的药物在以后的生活。有三个主要因素促成了这种基于年龄的药物用途：1）敏感的应激反应系统; 2）脆弱的敏感期; 3）青春期的成熟过程。总之，这些因素可以解释为什么暴露于早期逆境会增加青春期滥用药物的风险。
ANDERSEN, S.L. and TEICHER, M.H. Desperately driven and no brakes: Developmental stress exposure and subsequent risk for substance abuse. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2008. Adverse life events are associated with a wide range of psychopathology, including an increased risk for substance abuse. In this review, we focus on the inter-relationship between exposure to adversity and brain development, and relate this to enhanced windows of vulnerability. This review encompasses clinical and preclinical data, drawing evidence from epidemiological studies, morphometric and functional imaging studies, and molecular biology and genetics. The interaction of exposure during a sensitive period and maturational events produces a cascade that leads to the initiation of substance use at younger ages, and increases the likelihood of addiction by adolescence or early adulthood. A stress-incubation/corticolimbic dysfunction model is proposed based on the interplay of stress exposure, development stage, and neuromaturational events that may explain the seeking of specific classes of drugs later in life. Three main factors contribute to this age-based progression of increased drug use: 1) a sensitized stress response system; 2) sensitive periods of vulnerability; and 3) maturational processes during adolescence. Together, these factors may explain why exposure to early adversity increases risk to abuse substances during adolescence.
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影响因子：
7.6
作者：
Andersen, SL;Teicher, MH
通讯作者：
Teicher, MH
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
3.4
作者：
Barrot, M;Marinelli, M;Piazza, PV
通讯作者：
Piazza, PV
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL
影响因子：
7.6
作者：
Caldji, C;Francis, D;Meaney, MJ
通讯作者：
Meaney, MJ