Mechanisms and Management of Itch in Dry Skin.
Mechanisms and Management of Itch in Dry Skin.
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DOI：
10.2340/00015555-3344
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发表时间：
2020-01-15
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性瘙痒是一种沉重的临床问题，通常伴随着病理性皮肤干燥病症，如特应性皮炎，和全身性疾病，如肾脏疾病，其病理机制和治疗方法尚不清楚。研究与皮肤干燥相关的瘙痒机制的基本小鼠模型之一是丙酮和乙醚的混合物，然后是水。使用丙酮和乙醚随后水模型的动物研究已经揭示了许多介质和受体，例如mas相关的G蛋白偶联受体家族、瞬时受体电位和趋化因子，负责瘙痒及其超敏性，支持干燥皮肤诱导的瘙痒是组胺非依赖性途径的假设。神经元和非神经元细胞在瘙痒的发生、调节和致敏中的相互作用已获得新的见解。因此，已经开发了几种治疗瘙痒的选择。本文综述了干性皮肤瘙痒的最新发病机制和治疗策略。
Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the acetone and ether followed by water model have revealed that many mediators and receptors, e.g. mas-related G protein-coupled receptor family, transient receptor potential, and chemokines, are responsible for itch and its hypersensitivity, supporting the hypothesis that dry skin-induced itch is a histamine-independent pathway. New insights have been acquired into the interplay between neurones and non-neuronal cells in the initiation, modulation, and sensitization of itch. Several therapeutic options for itching have thus been developed. This review summarizes the updated pathogenesis and therapeutic strategies for itch in dry skin conditions.
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影响因子：
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