Salmonella Typhi Stool Shedding by Patients With Enteric Fever and Asymptomatic Chronic Carriers in an Endemic Urban Setting.

Salmonella Typhi Stool Shedding by Patients With Enteric Fever and Asymptomatic Chronic Carriers in an Endemic Urban Setting.
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DOI:
10.1093/infdis/jiab476
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发表时间:
2021-12-20
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Qadri F
Qadri F
中科院分区:
其他
文献类型:
--
作者:
Khanam F;Darton TC;Meiring JE;Kumer Sarker P;Kumar Biswas P;Bhuiyan MAI;Hasan Rajib N;Tonks S;Pollard AJ;Clemens JD;Qadri F

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肠道沙门氏菌血清型伤寒沙门氏菌(S. Typhi)在粪便中脱落的负担及其对地方性环境中传播的贡献尚不清楚。在被动监测中,在332例伤寒菌血症患者的恢复期发现了伤寒沙门氏菌的脱落,尽管在1年随访中没有持续。在血清监测参与者的年龄分层队列中测量抗毒胶囊(Vi) -免疫球蛋白(Ig) G滴度。对303名高抗- vi - igg滴度的参与者进行系统粪便取样,鉴定出1名无症状携带者。这些发现表明,在这种情况下,正在进行的伤寒沙门氏菌传播更有可能发生在急性恢复期病例中,尽管需要更好的方法来识别社区中真正的慢性携带者,以实现消除伤寒。
The burden of Salmonella enterica serotype Typhi (S. Typhi) shedding in stool and its contribution to transmission in endemic settings is unknown. During passive surveillance S. Typhi shedding was seen during convalescence in 332 bacteremic patient with typhoid, although none persisted at 1-year follow-up. Anti–virulence capsule (Vi)–immunoglobulin (Ig) G titers were measured in age-stratified cohort of serosurveillance participants. Systematic stool sampling of 303 participants with high anti–Vi-IgG titers identified 1 asymptomatic carrier with shedding. These findings suggest that ongoing S. Typhi transmission in this setting is more likely to occur from acute convalescent cases, although better approaches are needed to identify true chronic carriers in the community to enable typhoid elimination.
DOI: 10.1093/infdis/146.6.724
发表时间: 1982-01-01
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