Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.
Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.
复制标题
季节性重度抑郁症患者中可溶性环氧化物水解酶衍生的氧脂素的改变：一项探索性研究。
DOI：
10.1016/j.psychres.2017.02.056
复制
发表时间：
2017-06
影响因子：
11.3
通讯作者：
Swardfager W
中科院分区：
文献类型：
--
作者：
Hennebelle M;Otoki Y;Yang J;Hammock BD;Levitt AJ;Taha AY;Swardfager W
许多细胞色素p450衍生的脂质促进炎症的消退，与它们的可溶性环氧化物水解酶（sEH）衍生的氧化脂质分解产物相反。在这里，我们比较了具有季节性模式（MDD-s）的重度抑郁症参与者的血浆氧脂素和前体脂肪酸在不同季节之间的差异。在夏季和秋季招募的有mdd病史的健康参与者在冬季随访。在两次访问中，进行结构化临床访谈（DSM-5标准）和贝克抑郁量表II （BDI-II）。采用液相色谱串联质谱法（LC- MS/MS）测定未酯化和总氧脂质池的含量。采用气相色谱法测定前体脂肪酸含量。在9名冬季符合抑郁标准的基线健康未服药的参与者中，BDI-II评分从4.9±4.4增加到19.9±7.7。四种seh衍生的氧化脂类在冬季与夏秋季相比增加，具有中等到较大的效应量。自氧化产物（未酯化的环氧酮-十八二烯酸）和脂氧合酶衍生的13-羟基-十八二烯酸在冬季也有所增加。细胞色素p450衍生的20- cooh -白三烯B4（未酯化）和总14(15)-环氧二碳四烯酸以及seh衍生的14,15-二羟基二碳三烯酸（未酯化）在冬季减少。我们得出结论，冬季抑郁与细胞色素p450-和sEH衍生的氧化脂素的变化有关，表明由sEH介导的omega-6和omega-3脂肪酸代谢的季节性变化可能是症状性mdd的炎症状态的基础。
Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC- MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9 ± 4.4 to 19.9 ± 7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoc- tadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.
登录
查看更多内容
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
6.5
作者：
Fischer, Robert;Konkel, Anne;Schunck, Wolf-Hagen
通讯作者：
Schunck, Wolf-Hagen
影响因子：
6.5
作者：
Ichihara, Ken'ichi;Fukubayashi, Yumeto
通讯作者：
Fukubayashi, Yumeto
影响因子：
7.6
作者：
Hannestad, Jonas;DellaGioia, Nicole;Bloch, Michael
通讯作者：
Bloch, Michael
影响因子：
6.6
作者：
Maes, Michael;Mihaylova, Ivanka;Bosmans, Eugene
通讯作者：
Bosmans, Eugene