Head-up tilt does not enhance prostate tumor perfusion or oxygenation in young rats.
Head-up tilt does not enhance prostate tumor perfusion or oxygenation in young rats.
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头部倾斜不会增强年轻大鼠的前列腺肿瘤灌注或氧合。
DOI：
10.14814/phy2.15548
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发表时间：
2022-12
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
实体瘤含有导致抗癌治疗耐药性的缺氧区域。因此，减轻肿瘤缺氧可能会增强通常用于前列腺癌患者的放射治疗的功效。通过抬头倾斜（HUT）增加前列腺灌注压可能会增加前列腺肿瘤灌注并减少缺氧。本研究的目的是确定通过 70° HUT 增加血管静压梯度是否会增加前列腺癌临床前原位模型中的肿瘤灌注并减少肿瘤缺氧。雄性哥本哈根大鼠 (n = 17) 原位注射 Dunning R-3327 (AT-1) 前列腺腺癌细胞以诱导前列腺肿瘤。肿瘤形成后，在水平（0°）和70° HUT位置期间测量大鼠的前列腺肿瘤灌注和缺氧。为了将静水柱的大小与人类的静水柱大小进行比较，使用超声波测量男性受试者的心脏到前列腺的距离，以估计直立姿势下的前列腺血管静水压。在年轻大鼠中，70° HUT 与水平位置相比，在前列腺肿瘤灌注或前列腺肿瘤缺氧方面没有检测到差异。然而，从回顾性研究来看，年轻大鼠前列腺血管对HUT的抵抗力增加，而老年大鼠则缺乏这种反应。年轻大鼠中从现有功能性脉管系统中选择出来的肿瘤血管可能足以抵消老年大鼠中 HUT 引起的灌注压增加。此外，在人类中，前列腺水平的估计静水柱比大鼠高五倍。因此，70° HUT 可能会引起人类前列腺/前列腺肿瘤血流量的增加，而在大鼠中未观察到。血流量很大程度上取决于灌注压，可以通过身体位置来控制。在这里，我们测试了这样的假设：随着头部倾斜，原位前列腺肿瘤中静水压的增加会增加肿瘤的血流量。尽管灌注压略有升高，但我们没有观察到肿瘤血流量显着增加或缺氧减少。
Solid tumors contain hypoxic regions that contribute to anticancer therapy resistance. Thus, mitigating tumor hypoxia may enhance the efficacy of radiation therapy which is commonly utilized for patients with prostate cancer. Increasing perfusion pressure in the prostate with head‐up tilt (HUT) may augment prostate tumor perfusion and decrease hypoxia. The purpose of this study was to determine if an increase in the vascular hydrostatic gradient via 70° HUT increases tumor perfusion and decreases tumor hypoxia in a preclinical orthotopic model of prostate cancer. Male Copenhagen rats (n = 17) were orthotopically injected with Dunning R‐3327 (AT‐1) prostate adenocarcinoma cells to induce prostate tumors. After tumors were established, prostate tumor perfusion and hypoxia were measured in rats during level (0°) and 70° HUT positions. To compare the magnitude of the hydrostatic column to that present in humans, ultrasound was used to measure the heart to prostate distance in male human subjects to estimate the prostate vascular hydrostatic pressure with the upright posture. In young rats, no differences were detected in prostate tumor perfusion or prostate tumor hypoxia with 70° HUT versus the level position. However, from the retrospective study, young rats increased prostate vascular resistance to HUT, whereas aged rats lacked this response. Tumor vessels co‐opted from existing functional vasculature in young rats may be sufficient to negate increases in perfusion pressure with HUT seen in aged rats. Additionally, in humans, the estimated hydrostatic column at the level of the prostate is five times greater than that of the rat. Therefore, 70° HUT may elicit increases in prostate/prostate tumor blood flow in humans that is not seen in rats. Blood flow is largely dependent on perfusion pressure, which can be manipulated by body position. Here, we tested the hypothesis that, with head‐up tilt, the increased hydrostatic pressure in orthotopic prostate tumors would increase tumor blood flow. Despite slightly elevated perfusion pressures, we did not observe significant increases in tumor blood flow or reductions in hypoxia.
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影响因子：
10.3
作者：
McCullough, Danielle J.;Stabley, John N.;Behnke, Bradley J.
通讯作者：
Behnke, Bradley J.
DOI：
10.1016/j.ijrobp.2005.03.049
发表时间：
2005-07-15
影响因子：
7
作者：
Ljungkvist, ASE;Bussink, J;van der Kogel, AJ
通讯作者：
van der Kogel, AJ
DOI：
10.1111/j.1532-5415.1989.tb05684.x
发表时间：
1989-06-01
影响因子：
6.3
作者：
JANSEN, RWMM;LENDERS, JWM;HOEFNAGELS, WHL
通讯作者：
HOEFNAGELS, WHL
DOI：
10.1152/ajpregu.1999.276.1.r203
发表时间：
1999-01-01
影响因子：
2.8
作者：
Minson, CT;Wladkowski, SL;Kenney, WL
通讯作者：
Kenney, WL
某些人类肺癌的组织学结构以及对放射疗法的可能影响。
影响因子：
8.8
作者：
THOMLINSON, R H;GRAY, L H
通讯作者：
GRAY, L H