Exosome-Autophagy Crosstalk in Enveloped Virus Infection.
Exosome-Autophagy Crosstalk in Enveloped Virus Infection.
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DOI：
10.3390/ijms241310618
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发表时间：
2023-06-25
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
外泌体是主要存在于体液中的细胞外囊泡，参与各种生理过程。自噬是一种细胞内降解机制，通过形成双膜自噬体来清除蛋白质和受损的细胞器。这些自噬体随后与溶酶体合并以降解靶标。自噬与内体/外泌体途径的相互作用可以发生在不同的阶段，对正常生理和人类疾病产生重要影响。外泌体和自噬途径之间的相互作用是复杂的。外泌体通过诱导细胞内自噬发挥细胞保护作用，而自噬调节外泌体的生物发生和降解。研究表明外泌体和自噬参与了许多包膜病毒的感染过程。包膜病毒由病毒核酸、蛋白质或病毒粒子组成，可被包裹在外泌体内，并通过外泌体运输在细胞间转移。因此，外泌体在某些病毒性疾病的感染中起着至关重要的作用。本文综述了外泌体与自噬的相互作用及其在包膜病毒感染中的意义，从而为包膜病毒感染的发病机制和疫苗研究提供有价值的见解。
Exosomes, which are extracellular vesicles (EVs) predominantly present in bodily fluids, participate in various physiological processes. Autophagy, an intracellular degradation mechanism, eliminates proteins and damaged organelles by forming double-membrane autophagosomes. These autophagosomes subsequently merge with lysosomes for target degradation. The interaction between autophagy and endosomal/exosomal pathways can occur at different stages, exerting significant influences on normal physiology and human diseases. The interplay between exosomes and the autophagy pathway is intricate. Exosomes exhibit a cytoprotective role by inducing intracellular autophagy, while autophagy modulates the biogenesis and degradation of exosomes. Research indicates that exosomes and autophagy contribute to the infection process of numerous enveloped viruses. Enveloped viruses, comprising viral nucleic acid, proteins, or virions, can be encapsulated within exosomes and transferred between cells via exosomal transport. Consequently, exosomes play a crucial role in the infection of certain viral diseases. This review presents recent findings on the interplay between exosomes and autophagy, as well as their implications in the infection of enveloped viruses, thereby offering valuable insights into the pathogenesis and vaccine research of enveloped virus infection.
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影响因子：
5.2
作者：
Bello-Morales R;López-Guerrero JA
通讯作者：
López-Guerrero JA
影响因子：
5.4
作者：
Carpenter, John E.;Jackson, Wallen;Grose, Charles
通讯作者：
Grose, Charles
影响因子：
5.4
作者：
Buckingham EM;Jarosinski KW;Jackson W;Carpenter JE;Grose C
通讯作者：
Grose C
影响因子：
7.5
作者：
Alem F;Olanrewaju AA;Omole S;Hobbs HE;Ahsan N;Matulis G;Brantner CA;Zhou W;Petricoin EF;Liotta LA;Caputi M;Bavari S;Wu Y;Kashanchi F;Hakami RM
通讯作者：
Hakami RM
影响因子：
56.9
作者：
Carlton, Jez G.;Martin-Serrano, Juan
通讯作者：
Martin-Serrano, Juan