Critical windows of exposure to household pesticides and risk of childhood leukemia.
Critical windows of exposure to household pesticides and risk of childhood leukemia.
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DOI：
10.1289/ehp.02110955
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发表时间：
2002-09
影响因子：
10.4
通讯作者：
Reynolds P
中科院分区：
文献类型：
--
作者：
Ma X;Buffler PA;Gunier RB;Dahl G;Smith MT;Reinier K;Reynolds P
北加州儿童白血病研究检查了家庭农药暴露的潜在病因作用。 1995-1999年间，快速确定了162名新诊断白血病患者（0-14岁），并从出生登记处随机选择了162名匹配的对照受试者。从出生前 1 年到出生后 3 年的任何时间使用专业害虫防治服务都与儿童白血病风险显着增加相关[比值比 (OR) = 2.8； 95% 置信区间 (CI)，1.4-5.7]，第 2 年期间的暴露与最高风险相关（OR = 3.6；95% CI，1.6-8.3）。怀孕前 3 个月、怀孕以及第 1、2、3 年接触杀虫剂的 OR 分别为 1.8 (95% CI, 1.1-3.1)、2.1 (95% CI, 1.3-3.5)、1.7 (95% CI, 1.0-2.9)、1.6 (95% CI, 1.0-2.7) 和 1.2 （95% CI，0.7-2.1）。生命早期接触杀虫剂似乎比以后接触杀虫剂更为重要，并且在怀孕期间观察到接触杀虫剂的风险最高。此外，更频繁地接触杀虫剂与更高的风险相关。与杀虫剂相反，除草剂与白血病之间的关联较弱且不显着。农药还根据其使用地点进行分组。暴露于室内杀虫剂与风险增加相关，而暴露于室外杀虫剂则没有观察到显着关联。研究结果表明，接触家用杀虫剂与儿童白血病风险升高相关，并进一步表明接触时间和地点的重要性。
The potential etiologic role of household pesticide exposures was examined in the Northern California Childhood Leukemia Study. A total of 162 patients (0-14 years old) with newly diagnosed leukemia were rapidly ascertained during 1995-1999, and 162 matched control subjects were randomly selected from the birth registry. The use of professional pest control services at any time from 1 year before birth to 3 years after was associated with a significantly increased risk of childhood leukemia [odds ratio (OR) = 2.8; 95% confidence interval (CI), 1.4-5.7], and the exposure during year 2 was associated with the highest risk (OR = 3.6; 95% CI, 1.6-8.3). The ORs for exposure to insecticides during the 3 months before pregnancy, pregnancy, and years 1, 2, and 3 were 1.8 (95% CI, 1.1-3.1), 2.1 (95% CI, 1.3-3.5), 1.7 (95% CI, 1.0-2.9), 1.6 (95% CI, 1.0-2.7), and 1.2 (95% CI, 0.7-2.1), respectively. Insecticide exposures early in life appear to be more significant than later exposures, and the highest risk was observed for exposure during pregnancy. Additionally, more frequent exposure to insecticides was associated with a higher risk. In contrast to insecticides, the association between herbicides and leukemia was weak and nonsignificant. Pesticides were also grouped based on where they were applied. Exposure to indoor pesticides was associated with an increased risk, whereas no significant association was observed for exposure to outdoor pesticides. The findings suggest that exposure to household pesticides is associated with an elevated risk of childhood leukemia and further indicate the importance of the timing and location of exposure.
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影响因子：
20.3
作者：
Wiemels, JL;Ford, AM;Greaves, M
通讯作者：
Greaves, M
影响因子：
8.4
作者：
Meinert, R;Kaatsch, P;Michaelis, J
通讯作者：
Michaelis, J
影响因子：
168.9
作者：
Wiemels, JL;Cazzaniga, G;Greaves, MF
通讯作者：
Greaves, MF
影响因子：
8.3
作者：
Lu, CS;Fenske, RA;Kalman, D
通讯作者：
Kalman, D
DOI：
10.1002/mpo.2950190209
发表时间：
1991-01-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
SCHWARTZBAUM, JA;GEORGE, SL;DAVIS, B
通讯作者：
DAVIS, B