Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
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DOI：
10.1136/bjo.2007.123190
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发表时间：
2008-04
期刊：
影响因子：
--
通讯作者：
Lotery AJ
中科院分区：
文献类型：
--
作者：
Goverdhan SV;Ennis S;Hannan SR;Madhusudhana KC;Cree AJ;Luff AJ;Lotery AJ
目的：确定4种表达相关的细胞因子基因多态性是否与年龄相关性黄斑变性(AMD)相关。采用5‘核苷酸酶标记法对4 78例AMD患者和5 5 5例正常对照的IL 1β-511C/T、IL 6-174C/G、IL 8-251A/T和抗炎性IL 10-1082G/A等位基因进行了基因分型。使用等位基因频率分析与AMD的关联。IL 8基因启动子区-251a等位基因在AMD患者中的分布频率明显高于对照组(P=0.037，OR=1.2 1，95%CI=1.0 1~1.4 4)。调整了年龄、性别、体重指数、当前吸烟和既往吸烟状况后，与老年性黄斑变性的关联没有显著改变(校正p值=0.043，OR=1.2 3，95%CI=1.0~1.5 0)。促炎性纯合子IL8-251AA基因是AMD的重要危险因素。这可能会对未来以这种细胞因子为靶点的生物制剂的治疗产生影响。
To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD). DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1β –511C/T, IL6 –174C/G, IL8 –251A/T and anti-inflammatory IL10 –1082G/A cytokine polymorphisms using the 5′ nuclease TaqMan® assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies. The –251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50). The pro-inflammatory homozygous IL8 –251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.
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影响因子：
4.4
作者：
Higgins, GT;Wang, JH;Redmond, HP
通讯作者：
Redmond, HP
DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
2.1
作者：
Enzmann, V;Hollorn, M;Kohen, L
通讯作者：
Kohen, L
DOI：
10.1084/jem.180.6.2371
发表时间：
1994-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Matsuda M;Salazar F;Petersson M;Masucci G;Hansson J;Pisa P;Zhang QJ;Masucci MG;Kiessling R
通讯作者：
Kiessling R
DOI：
10.1084/jem.179.5.1409
发表时间：
1994-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Smith DR;Polverini PJ;Kunkel SL;Orringer MB;Whyte RI;Burdick MD;Wilke CA;Strieter RM
通讯作者：
Strieter RM