Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd(3)N@C(80): A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.
Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd(3)N@C(80): A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.
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DOI：
10.1021/acsami.7b04718
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发表时间：
2017-05-31
影响因子：
9.5
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Li T;Xiao L;Yang J;Ding M;Zhou Z;LaConte L;Jin L;Dorn HC;Li X
研究了新型磁共振成像（MRI）造影剂三金属氮化物内嵌富勒烯羧基-Gd3N@C80的抗氧化和抗炎作用。所有氢查拉酮和羧基官能化的富勒烯表现出有效的自由基（羟基和超氧阴离子）清除，而羧基-Gd3N@C80更有效地衰减脂多糖（LPS）诱导的氧化应激在巨噬细胞。羧基-Gd3N@C80还抑制LPS诱导的促炎诱导型一氧化氮合酶和肿瘤坏死因子-α的mRNA表达，并上调抗氧化酶轴Nrf 2和血红素加氧酶-1，可能通过ERK而不是AKT信号通路。因此，羧基-Gd3N@C80在成为一种新型治疗诊断纳米平台方面具有很大的前景，用于同时向炎症相关疾病提供MRI对比和治疗功能。
Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd3N@C80, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd3N@C80 more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd3N@C80 also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-Gd3N@C80 held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.
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