Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice
Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice
复制标题
牙齿缺失抑制成年小鼠齿状回的神经发生
DOI：
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发表时间：
2014
影响因子：
6.1
通讯作者：
Lan Yang
中科院分区：
文献类型：
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作者：
Shaochen Su;Tao Qi;Baoli Su;Huibin Gu;Jianlin Wang;Lan Yang
牙齿脱落已被证明会影响小鼠的学习和记忆，并增加患阿尔茨海默病的风险。齿状回与认知功能密切相关。这项研究假设牙齿脱落会影响齿状回的神经元。成年雄性小鼠随机分为牙齿缺失组和正常对照组。在牙齿缺失组中，拔除左侧上颌和下颌磨牙。正常对照组小鼠不接受任何干预。免疫荧光染色显示，双皮质素和神经元核抗原阳性细胞的密度和吸光度在牙齿脱落组低于正常对照组。这些数据表明，牙齿脱落可能会抑制成年小鼠齿状回的神经发生。
Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alzheimer's disease. The dentate gyrus is strongly associated with cognitive function. This study hypothesized that tooth loss affects neurons in the dentate gyrus. Adult male mice were randomly assigned to either the tooth loss group or normal control group. In the tooth loss group, the left maxillary and mandibular molars were extracted. Normal control mice did not receive any intervention. Immunofluorescence staining revealed that the density and absorbance of doublecortin- and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice.
影响因子：
24.8
作者：
Leuner B;Gould E
通讯作者：
Gould E
大脑中动脉闭塞后啮齿动物大脑中一氧化氮合酶活性的诱导。
影响因子：
2.5
作者：
Yoshida,T;Waeber,C;Huang,Z;Moskowitz,MA
通讯作者：
Moskowitz,MA