Structural plasticity and hippocampal function.
Structural plasticity and hippocampal function.
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DOI：
10.1146/annurev.psych.093008.100359
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发表时间：
2010
影响因子：
24.8
通讯作者：
Gould E
中科院分区：
文献类型：
--
作者：
Leuner B;Gould E
海马体是哺乳动物大脑的一个区域，它显示出令人印象深刻的结构重组能力。先前存在的神经回路经历树突复杂性和突触数量的修改，并且通过神经发生过程形成全新的神经连接。这些类型的结构性变化曾经被认为仅限于发展。然而，现在普遍认为海马体在整个生命过程中保持结构塑性。本文综述了海马体在生命周期中的结构可塑性，包括如何通过实验研究。调制的结构可塑性的各种经验因素，以及它可能在海马功能，如学习和记忆，焦虑，压力调节的可能作用也被考虑。虽然在许多这些领域取得了重大进展，但我们强调仍然存在一些悬而未决的问题。
The hippocampus is a region of the mammalian brain that shows an impressive capacity for structural reorganization. Preexisting neural circuits undergo modifications in dendritic complexity and synapse number, and entirely novel neural connections are formed through the process of neurogenesis. These types of structural change were once thought to be restricted to development. However, it is now generally accepted that the hippocampus remains structurally plastic throughout life. This article reviews structural plasticity in the hippocampus over the lifespan, including how it is investigated experimentally. The modulation of structural plasticity by various experiential factors as well as the possible role it may have in hippocampal functions such as learning and memory, anxiety, and stress regulation are also considered. Although significant progress has been made in many of these areas, we highlight some of the outstanding issues that remain.
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影响因子：
5.3
作者：
Bull, ND;Bartlett, PF
通讯作者：
Bartlett, PF
影响因子：
7.8
作者：
Bauer, S;Patterson, PH
通讯作者：
Patterson, PH
DOI：
10.1073/pnas.91.23.11217
发表时间：
1994-11-08
影响因子：
11.1
作者：
BARNEA, A;NOTTEBOHM, F
通讯作者：
NOTTEBOHM, F
影响因子：
2.5
作者：
Bain, MJ;Dwyer, SM;Rusak, B
通讯作者：
Rusak, B
影响因子：
3.4
作者：
Burns, KA;Kuan, CY
通讯作者：
Kuan, CY