Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine.
Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine.
复制标题
增加天然叶酸摄入量的饮食咨询：一项针对自由生活受试者的随机、安慰剂对照试验，旨在评估对血清叶酸和血浆总同型半胱氨酸的影响。
DOI：
10.1093/ajcn/76.4.758
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Wendy Aitken
中科院分区：
文献类型：
--
作者：
B. Venn;J. Mann;Sheila M. Williams;L. Riddell;A. Chisholm;Michelle J. Harper;Wendy Aitken
背景
BACKGROUND
The association between vascular disease and elevated plasma total homocysteine (tHcy) concentrations is caused, in part, by inadequate intakes of dietary folate. Increasing folate intake either through supplements or foods naturally rich in folates has been shown to decrease tHcy concentrations.
OBJECTIVE
The aim of this study was to determine whether a similar reduction in tHcy was possible in free-living persons receiving dietary counseling.
DESIGN
The study included a 4-wk placebo-controlled dietary intervention trial in which participants consumed either unfortified breakfast cereal (control group) or an extra 350 micro g folate derived from food/d (dietary group). Serum folate and tHcy concentrations in both groups were measured before and after the intervention period, and the concentrations in the dietary group were also measured 17 wk after the intervention period.
RESULTS
During the 4-wk intervention, mean dietary folate intake in the dietary group increased from 263 (95% CI: 225, 307) to 618 micro g/d (535, 714), resulting in a mean increase in serum folate of 37% (15%, 63%) and a decrease in tHcy from 12.0 (10.9, 13.3) to 11.3 micro mol/L (10.2, 12.5). A further decrease in tHcy occurred in the dietary group during follow-up, with a final tHcy concentration of 9.7 micro mol/L (8.8, 10.8).
CONCLUSIONS
Increasing natural folate intake improved folate status and decreased tHcy concentrations to an extent that may significantly reduce the risk of vascular disease. Dietary modification may have advantages over folic acid fortification because the altered food-consumption patterns lead to increased intakes of several vitamins and minerals and decreased intakes of saturated fatty acids.
叶酸强化食品——多少才足够？
DOI：
10.1056/nejm200005113421911
发表时间：
2000
期刊：
The New England journal of medicine
影响因子：
--
作者：
Mills,JL
通讯作者：
Mills,JL
影响因子：
37.8
作者：
Jacques, PF;Bostom, AG;Rozen, R
通讯作者：
Rozen, R
影响因子：
37.8
作者：
Appel, LJ;Miller, ER;Selhub, J
通讯作者：
Selhub, J