Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice.
Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice.
复制标题
DOI：
10.1186/0717-6287-47-8
复制
发表时间：
2014-04-01
影响因子：
6.7
通讯作者：
Dkhil MA
中科院分区：
文献类型：
--
作者：
Dkhil MA
血吸虫病是由血吸虫属蠕虫寄生虫引起的。小檗碱氯化物 (BER) 是一种异喹啉生物碱，因其抗寄生虫、抗氧化和保肝特性而在体内使用。在这项研究中，比较了 BER 和吡喹酮对血吸虫病诱导的小鼠肝组织氧化应激程度的保护作用。曼氏沙门氏菌能够诱发肝脏炎症和损伤，证据如下：(i) 炎症细胞浸润、血窦扩张和空泡肝细胞增加，(ii) 肝脏匀浆中丙氨酸和天冬氨酸转氨酶水平降低，碱性磷酸酶、γ-谷氨酰转移酶水平增加，(iii) 一氧化氮和硫代巴比妥酸反应物质的产生增加，(iv) 降低谷胱甘肽水平以及过氧化氢酶和超氧化物歧化酶的活性分别降低。所有这些感染引起的参数在 BER 治疗期间都发生了显着改变。特别是，小檗碱可以抵消曼氏沙门氏菌引起的谷胱甘肽损失以及过氧化氢酶和超氧化物歧化酶的活性。基于这些结果，得出结论：小檗碱可以改善血吸虫病引起的现有肝损伤和氧化应激状况。
Schistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice. S. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase. Based on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.
登录
查看更多内容
DOI：
10.4269/ajtmh.1968.17.38
发表时间：
1968-01-01
影响因子：
3.3
作者：
CHEEVER, AW
通讯作者：
CHEEVER, AW
影响因子：
1.5
作者：
Cunha, G. M. M.;Silva, V. M. A.;Freire, A. C. G.
通讯作者：
Freire, A. C. G.
影响因子：
3.5
作者：
REITMAN, S;FRANKEL, S
通讯作者：
FRANKEL, S
影响因子：
6.4
作者：
Kim, TS;Kang, BY;Kim, SH
通讯作者：
Kim, SH
影响因子：
1.3
作者：
OLIVIER, L;STIREWALT, MA
通讯作者：
STIREWALT, MA