The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.
The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.
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DOI：
10.1093/nar/gkx1134
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发表时间：
2018-01-04
影响因子：
14.9
通讯作者：
Finn RD
中科院分区：
文献类型：
--
作者：
Rawlings ND;Barrett AJ;Thomas PD;Huang X;Bateman A;Finn RD
MEROPS数据库（http：//www.ebi.ac.uk/merops/）是关于肽酶、其底物和抑制剂的综合信息来源。层次分类是：蛋白质-种、科、族，在每一级具有标识符。MEROPS网站于2017年迁移到EMBL-EBI，需要重构代码库和提供的服务。序列搜索界面已发生变化，可以使用HMMER、FastA和BLASTP在EMBL-EBI上搜索MEROPS蛋白质序列文库。MEROPS和PANTHER数据库之间在科和蛋白质物种水平上建立了交叉引用，这将有助于改善资源之间的管理和覆盖范围。由于MEROPS序列库的规模不断扩大，今后将只增加已鉴定蛋白质的序列，以及具有进化、医学或商业意义的生物体的完全测序基因组。作为一个例子，肽酶同源物在四个蛋白质组从Asgard超门的古细菌，细菌和真核生物的蛋白质组已被确定和比较。这使人们对肽酶家族的起源和进化有了深入的了解，包括Asgard古菌中蛋白酶体组分数量的扩大以及生物体复杂性的增加。古细菌蛋白酶体复合物的新结构被假定。
The MEROPS database (http://www.ebi.ac.uk/merops/) is an integrated source of information about peptidases, their substrates and inhibitors. The hierarchical classification is: protein-species, family, clan, with an identifier at each level. The MEROPS website moved to the EMBL-EBI in 2017, requiring refactoring of the code-base and services provided. The interface to sequence searching has changed and the MEROPS protein sequence libraries can be searched at the EMBL-EBI with HMMER, FastA and BLASTP. Cross-references have been established between MEROPS and the PANTHER database at both the family and protein-species level, which will help to improve curation and coverage between the resources. Because of the increasing size of the MEROPS sequence collection, in future only sequences of characterized proteins, and from completely sequenced genomes of organisms of evolutionary, medical or commercial significance will be added. As an example, peptidase homologues in four proteomes from the Asgard superphylum of Archaea have been identified and compared to other archaean, bacterial and eukaryote proteomes. This has given insights into the origins and evolution of peptidase families, including an expansion in the number of proteasome components in Asgard archaeotes and as organisms increase in complexity. Novel structures for proteasome complexes in archaea are postulated.
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影响因子：
5.8
作者：
Tieku S;Hooper NM
通讯作者：
Hooper NM
影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
影响因子：
--
作者：
Rawlings, Neil D;Barrett, Alan J;Bateman, Alex
通讯作者：
Bateman, Alex
影响因子：
14.9
作者：
Finn RD;Clements J;Arndt W;Miller BL;Wheeler TJ;Schreiber F;Bateman A;Eddy SR
通讯作者：
Eddy SR
影响因子：
3.7
作者：
Barrett, Alan J.;Rawlings, Neil D.
通讯作者：
Rawlings, Neil D.