Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.
Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.
复制标题
与人工耳蜗核的下胶细胞上周围神经元网的年龄相关的上调。
DOI：
10.3389/fnagi.2023.1271008
复制
发表时间：
2023
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在衰老过程中，下丘（IC）的兴奋和抑制平衡被破坏，并成为听力损失的各个方面的基础。具体而言，年龄相关的改变，以GABA能神经传递的IC可能有助于较差的时间精度的特点，老年性耳聋。神经元周网（Perineuronalnets，PN）是细胞外基质的一种特殊形式，维持兴奋性/抑制性突触环境并降低结构可塑性。我们试图确定是否PN越来越多地包围在老年IC的细胞群，包括兴奋性下降的预测耳蜗核。我们结合紫藤花凝集素（WFA）染色的PN逆行追踪在三个年龄组的Fischer Brown Norway（FBN）大鼠。数据表明，具有PN的IC-CN细胞的百分比从年轻时的约10%增加到老年时的约20%。这在丘系和非丘系IC中都是真实的。此外，在向CN下行投射的同侧和对侧IC细胞上，PNs增加。这些结果表明，老年人IC-CN通路的结构可塑性降低，影响兴奋/抑制平衡，并可能导致与老年性耳聋相关的时间精度降低。
Disruptions to the balance of excitation and inhibition in the inferior colliculus (IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age-related alteration to GABAergic neurotransmission in the IC likely contributes to the poorer temporal precision characteristic of presbycusis. Perineuronal nets (PNs), a specialized form of the extracellular matrix, maintain excitatory/inhibitory synaptic environments and reduce structural plasticity. We sought to determine whether PNs increasingly surround cell populations in the aged IC that comprise excitatory descending projections to the cochlear nucleus. We combined Wisteria floribunda agglutinin (WFA) staining for PNs with retrograde tract-tracing in three age groups of Fischer Brown Norway (FBN) rats. The data demonstrate that the percentage of IC-CN cells with a PN doubles from ~10% at young age to ~20% at old age. This was true in both lemniscal and non-lemniscal IC. Furthermore, the increase of PNs occurred on IC cells that make both ipsilateral and contralateral descending projections to the CN. These results indicate that reduced structural plasticity in the elderly IC-CN pathway, affecting excitatory/inhibitory balance and, potentially, may lead to reduced temporal precision associated with presbycusis.
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DOI：
10.1111/bpa.13129
发表时间：
2023-01
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
通讯作者：
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影响因子：
4.2
作者：
Cai R;Montgomery SC;Graves KA;Caspary DM;Cox BC
通讯作者：
Cox BC
影响因子：
3.3
作者：
Bukalo, O;Schachner, M;Dityatev, A
通讯作者：
Dityatev, A
影响因子：
5.3
作者：
Balmer, Timothy S.;Trussell, Laurence O.
通讯作者：
Trussell, Laurence O.
影响因子：
2.8
作者：
Brückner, G;Grosche, J;Schachner, M
通讯作者：
Schachner, M