Iron deficiency in the elderly population, revisited in the hepcidin era.
Iron deficiency in the elderly population, revisited in the hepcidin era.
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DOI：
10.3389/fphar.2014.00083
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发表时间：
2014
影响因子：
5.6
通讯作者：
Girelli D
中科院分区：
文献类型：
--
作者：
Busti F;Campostrini N;Martinelli N;Girelli D
缺铁（ID）在老年人群中相对常见，在很大程度上导致了在生命的最后几十年观察到的高患病率贫血，这反过来对生活质量和生存都有重要影响。在老年受试者中，ID通常是多因素的，即由于多种同时发生的原因，包括饮食摄入或吸收不足、隐蔽性出血、药物。此外，由于老年人典型的多病性，导致贫血的其他疾病经常共存，使ID的诊断特别具有挑战性。老年人对铁的治疗也有问题，因为口服铁的反应通常很慢，很大一部分患者表现出难治性，需要繁琐的静脉给药。在过去的十年中，铁调节激素hepcidin的发现彻底改变了我们对铁病理生理学的理解。在这篇综述中，我们根据铁调节知识的最新进展重新审视老年人的ID，并讨论hepcidin如何帮助诊断和治疗这种常见的临床疾病。
Iron deficiency (ID) is relatively common among the elderly population, contributing substantially to the high prevalence of anemia observed in the last decades of life, which in turn has important implications both on quality of life and on survival. In elderly subjects, ID is often multifactorial, i.e., due to multiple concurring causes, including inadequate dietary intake or absorption, occult bleeding, medications. Moreover, because of the typical multimorbidity of aged people, other conditions leading to anemia frequently coexist and make diagnosis of ID particularly challenging. Treatment of ID is also problematic in elderly, since response to oral iron is often slow, with a substantial fraction of patients showing refractoriness and requiring cumbersome intravenous administration. In the last decade, the discovery of the iron regulatory hormone hepcidin has revolutionized our understanding of iron pathophysiology. In this review, we revisit ID among elderly people in the light of the impressive recent advances on knowledge of iron regulation, and discuss how hepcidin may help in diagnosis and treatment of this common clinical condition.
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影响因子：
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作者：
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