Mapping and comparing fMRI connectivity networks across species.
Mapping and comparing fMRI connectivity networks across species.
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DOI：
10.1038/s42003-023-05629-w
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发表时间：
2023-12-07
影响因子：
5.9
通讯作者：
Gozzi, Alessandro
中科院分区：
文献类型：
--
作者：
Pagani, Marco;Gutierrez-Barragan, Daniel;de Guzman, A. Elizabeth;Xu, Ting;Gozzi, Alessandro
神经成像技术的进步，特别是功能磁共振成像技术的进步，使人们能够以更高的时空分辨率在人脑中绘制出功能连接的分布模式。近年来，人们越来越有兴趣将这种方法扩展到啮齿动物和非人类灵长类动物，以了解功能磁共振连接的机制，并补充人类对功能连接组的研究。在这里，我们讨论当前跨物种功能磁共振连通性图谱的挑战和机遇。我们强调了通过多尺度的动物机制研究对脑(Dys)连通性的神经成像测量进行生理学解码的重要性。接下来，我们重点介绍一套管理哺乳动物跨物种连接网络组织的一般原则。这些包括进化上保守的网络系统的存在，占主导地位的功能连接的皮质轴，以及常见的地形保守的fMRI时空模式。我们最后描述了允许跨物种比较和推断功能磁共振连通性发现的新兴方法。随着神经科学家获得越来越复杂的扰动、计算和记录工具，跨物种功能磁共振成像为研究哺乳动物大脑在健康和疾病中的大规模组织提供了新的机会。这篇综述讨论了跨物种功能磁共振连通性图谱的挑战和机遇，并强调了一套管理哺乳动物连通性网络组织的一般原则。
Technical advances in neuroimaging, notably in fMRI, have allowed distributed patterns of functional connectivity to be mapped in the human brain with increasing spatiotemporal resolution. Recent years have seen a growing interest in extending this approach to rodents and non-human primates to understand the mechanism of fMRI connectivity and complement human investigations of the functional connectome. Here, we discuss current challenges and opportunities of fMRI connectivity mapping across species. We underscore the critical importance of physiologically decoding neuroimaging measures of brain (dys)connectivity via multiscale mechanistic investigations in animals. We next highlight a set of general principles governing the organization of mammalian connectivity networks across species. These include the presence of evolutionarily conserved network systems, a dominant cortical axis of functional connectivity, and a common repertoire of topographically conserved fMRI spatiotemporal modes. We finally describe emerging approaches allowing comparisons and extrapolations of fMRI connectivity findings across species. As neuroscientists gain access to increasingly sophisticated perturbational, computational and recording tools, cross-species fMRI offers novel opportunities to investigate the large-scale organization of the mammalian brain in health and disease. This review discusses the challenges and opportunities of fMRI connectivity mapping across species and highlights a set of general principles governing the organization of mammalian connectivity networks.
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影响因子：
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作者：
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通讯作者：
Calhoun, Vince D.
影响因子：
4.7
作者：
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通讯作者：
ABCD Imaging Acquisition Workgroup