Thermo-sensitive and photoluminescent hydrogels: Synthesis, characterization, and their drug-release property
Thermo-sensitive and photoluminescent hydrogels: Synthesis, characterization, and their drug-release property
复制标题
热敏和光致发光水凝胶：合成、表征及其药物释放特性
DOI：
10.1016/j.msec.2011.05.010
复制
发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Zhang, Faai
中科院分区：
文献类型：
--
作者：
Zhou, Li;Zhang, Faai
以聚N-异丙基丙烯酰胺（PNIPAM）和CdTe量子点（QDs）为交联剂，在温和条件下制备了具有半互穿网络结构、强光致发光和温敏性的多功能水凝胶.随着外界温度的升高，水凝胶的光致发光（PL）强度逐渐减弱，发射峰位置发生红移。随着温度的降低，凝胶的荧光强度和发射峰又恢复到初始值。此外，药物释放实验表明，多功能水凝胶的释放速率可以通过调节环境温度和PNIPAM的含量。此外，生物相容性超支化聚甘油官能化的QD（QD@ HPG）代替原始QD也可以掺入到水凝胶中，从而提供仍然可以表现出温度敏感的光致发光和药物释放行为的生物相容性水凝胶。
Multifunctional hydrogels that simultaneously possess semi-interpenetrating networks structure, strong photoluminescence, and temperature sensitivity were successfully fabricated based on the crosslink of poly(acrylamide) (PAAm) in the presence of poly(N-isopropylacrylamide) (PNIPAM) and CdTe quantum dots (QDs) at a mild condition. With the increase of external temperature, the photoluminescence (PL) intensity and emission peak of the hydrogels gradually decreased and red-shifted, respectively. Decreasing the temperature, the PL intensity and emission peak of the hydrogels could back to their initial values again. Moreover, drug-release experiments on the multifunctional hydrogels demonstrated that the release rate can be tuned by the environmental temperature and the content of PNIPAM. In addition, biocompatible hyperbranched polyglycerol functionalized QDs (QD@HPGs) instead of pristine QDs can also be incorporated into the hydrogels, affording biocompatible hydrogels which could still exhibit temperature-sensitive photoluminescence and drug-release behaviors.
登录
查看更多内容
影响因子：
9.5
作者：
R. Ghosh
通讯作者：
R. Ghosh
DOI：
10.1016/j.msec.2009.04.008
发表时间：
2009-08-31
影响因子：
7.9
作者：
Chen, Jun;Liu, Mingzhu;Ma, Liwei
通讯作者：
Ma, Liwei
影响因子：
29.4
作者：
Li, J;Hong, X;Li, TJ
通讯作者：
Li, TJ
影响因子：
--
作者：
Li Zhou;Li Zhou;Chao Gao;Weijian Xu
通讯作者：
Li Zhou;Li Zhou;Chao Gao;Weijian Xu
影响因子：
4.6
作者：
N. Morimoto;T. Ohki;K. Kurita;K. Akiyoshi
通讯作者：
N. Morimoto;T. Ohki;K. Kurita;K. Akiyoshi