Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats.
Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats.
复制标题
在福尔马林诱导的大鼠炎症性疼痛模型中，前扣带皮层对对侧电针至关重要，但对同侧电针则不然
DOI：
10.1186/1744-8069-7-61
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发表时间：
2011-08-22
期刊：
影响因子：
3.3
通讯作者：
Wan Y
中科院分区：
文献类型：
--
作者：
Yi M;Zhang H;Lao L;Xing GG;Wan Y
针灸和电针（EA）现在被广泛用于治疗疼痛等疾病。我们和其他人以前已经表明，电流频率，强度和治疗时间都显着影响EA的抗伤害性效应。有证据表明，刺激部位也会影响抗伤害性感受，在某些疼痛状态下，对侧施加于疼痛部位的EA更有效，但在其他状态下，对侧EA更有效。最近有报道说，局部腺苷A1受体负责同侧针刺，但具体是什么机制介导的对侧针刺或EA的抗伤害性效应仍不清楚。本研究采用100 Hz电针对福尔马林致炎性痛大鼠的同侧和对侧进行镇痛实验，观察了不同频率电针的镇痛作用及其机制。同侧和对侧EA减少了在福尔马林试验的第二阶段的爪抬起时间和衰减福尔马林诱导的条件性位置厌恶。侧位电针具有减少舔爪时间的额外效果，表明脊髓上机制。头端前扣带皮层（ACC）损伤完全取消对侧而不是同侧EA的抗伤害性效应。这些发现不是偏侧效应，因为将福尔马林注射到左或右后爪中产生了相似的结果。总之，这些结果表明不同刺激侧之间具有不同的抗伤害性效应和机制，并暗示有必要为不同的疼痛状态找到最佳刺激方案。
Acupuncture and electro-acupuncture (EA) are now widely used to treat disorders like pain. We and others have shown previously that current frequency, intensity and treatment duration all significantly influence the anti-nociceptive effects of EA. There is evidence that stimulating sites also affect the antinociception, with EA applied ipsilaterally to the pain site being more effective under some pain states but contralateral EA under others. It was recently reported that local adenosine A1 receptors were responsible for ipsilateral acupuncture, but what mechanisms specifically mediate the anti-nociceptive effects of contralateral acupuncture or EA remains unclear. In the present study, we applied 100 Hz EA on the ipsi- or contra-lateral side of rats with inflammatory pain induced by intra-plantar injection of formalin, and reported distinct anti-nociceptive effects and mechanisms between them. Both ipsi- and contra-lateral EA reduced the paw lifting time in the second phase of the formalin test and attenuated formalin-induced conditioned place aversion. Contralateral EA had an additional effect of reducing paw licking time, suggesting a supraspinal mechanism. Lesions of rostral anterior cingulate cortex (ACC) completely abolished the anti-nociceptive effects of contra- but not ipsi-lateral EA. These findings were not lateralized effects, since injection of formalin into the left or right hind paws produced similar results. Overall, these results demonstrated distinct anti-nociceptive effects and mechanisms between different stimulating sides and implied the necessity of finding the best stimulating protocols for different pain states.
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影响因子：
2.9
作者：
Sun, Jyh-Jang;Kung, Jeng Chuang;Shyu, Bai-Chuang
通讯作者：
Shyu, Bai-Chuang
影响因子：
3.3
作者：
Gemmell, C;O'Mara, SM
通讯作者：
O'Mara, SM
影响因子：
5.5
作者：
Wei, F;Zhuo, M
通讯作者：
Zhuo, M
影响因子：
2.9
作者：
WYSS, JM;SRIPANIDKULCHAI, K
通讯作者：
SRIPANIDKULCHAI, K
DOI：
10.1073/pnas.141218998
发表时间：
2001-07-03
影响因子：
11.1
作者：
Johansen, JP;Fields, HL;Manning, BH
通讯作者：
Manning, BH