The tumor proteasome as a novel target for gold(III) complexes: implications for breast cancer therapy.
The tumor proteasome as a novel target for gold(III) complexes: implications for breast cancer therapy.
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DOI：
10.1016/j.ccr.2009.01.032
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发表时间：
2009
影响因子：
20.6
通讯作者：
Dou QP
中科院分区：
文献类型：
--
作者：
Milacic V;Dou QP
虽然顺铂在治疗几种类型的人类癌症中起着至关重要的作用，但其广泛使用受到耐药性和相关毒副作用的限制。许多世纪以来，金和金络合物已被用于治疗各种疾病。近年来，由于金和铂的相似性，提出了使用金（III）络合物作为顺铂治疗的替代品。金（III）与铂（II）是等电子的，并且金（III）络合物具有与铂（II）络合物（例如顺铂）相同的正方形平面几何形状。虽然最初认为金（III）络合物可能具有与顺铂相同的分子靶点，但几行数据表明，金络合物靶向的是蛋白质而不是DNA。我们最近评估了几个金（III）二硫代氨基甲酸酯对人乳腺癌细胞在体外和体内的细胞毒性和抗癌作用。我们已经确定了肿瘤蛋白酶体作为金（III）配合物的一个重要目标，并已表明，蛋白酶体抑制金（III）配合物与乳腺癌细胞在体外和体内诱导凋亡。此外，金（III）二硫代氨基甲酸盐配合物的人乳腺癌荷瘤裸鼠的治疗与肿瘤生长抑制，支持其潜在的发展乳腺癌治疗的意义。
Although cisplatin plays a vital role in the treatment of several types of human cancer, its wide use is limited by the development of drug resistance and associated toxic side effects. Gold and gold complexes have been used to treat a wide range of ailments for many centuries. In recent years, the use of gold(III) complexes as an alternative to cisplatin treatment was proposed due to the similarities of gold and platinum. Gold(III) is isoelectronic with platinum(II) and gold(III) complexes have the same square-planar geometries as platinum(II) complexes, such as cisplatin. Although it was originally thought that gold(III) complexes might have the same molecular target as cisplatin, several lines of data indicated that proteins, rather than DNA, are targeted by gold complexes. We have recently evaluated cytotoxic and anti-cancer effects of several gold(III) dithiocarbamates against human breast cancer cells in vitro and in vivo. We have identified the tumor proteasome as an important target for gold(III) complexes and have shown that proteasome inhibition by gold(III) complexes is associated with apoptosis induction in breast cancer cells in vitro and in vivo. Furthermore, treatment of human breast tumor-bearing nude mice with a gold(III) dithiocarbamate complex was associated with tumor growth inhibition, supporting the significance of its potential development for breast cancer treatment.
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女性乳腺癌发病率和死亡率的全球模式不断变化。
影响因子：
7.4
作者：
Bray, F;McCarron, P;Parkin, DM
通讯作者：
Parkin, DM
DOI：
10.1039/c39730000878
发表时间：
1973-01-01
影响因子：
--
作者：
BORDIGNON, E;CATTALINI, L;SCATTURIN, A
通讯作者：
SCATTURIN, A
影响因子：
3.9
作者：
Casas, JS;Castaño, MV;Abram, U
通讯作者：
Abram, U
影响因子：
3
作者：
Alderden, RA;Hall, MD;Hambley, TW
通讯作者：
Hambley, TW
影响因子：
2.3
作者：
Aldinucci, Donatella;Lorenzon, Debora;Fregona, Dolores
通讯作者：
Fregona, Dolores