Design and demonstration of a small-animal up-conversion imager.
Design and demonstration of a small-animal up-conversion imager.
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DOI:
10.1364/oe.16.021731
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发表时间:
2008-12-22
期刊:
影响因子:
3.8
通讯作者:
Mahmood U
中科院分区:
文献类型:
--
作者:
Salthouse C;Hildebrand S;Weissleder R;Mahmood U
This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.
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