RhoA/ROCK Signaling Regulates Drp1-Mediated Mitochondrial Fission During Collective Cell Migration.
RhoA/ROCK Signaling Regulates Drp1-Mediated Mitochondrial Fission During Collective Cell Migration.
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RhoA/ROCK 信号传导在集体细胞迁移过程中调节 Drp1 介导的线粒体分裂
DOI：
10.3389/fcell.2022.882581
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发表时间：
2022
影响因子：
5.5
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Qu C;Yang W;Kan Y;Zuo H;Wu M;Zhang Q;Wang H;Wang D;Chen J
集体迁移在发育，身体和病理过程中起关键作用，并且需要动态的肌动蛋白网络，以改变单个细胞中的细胞粘合剂和细胞 - 细胞的动态网络。 During collective migration is not clear. Here, we demonstrate that proper regulation of mitochondrial dynamics is critical for collective migration of Drosophila border cells during oogenesis, and misregulation of fission or fusion results in reduction of ATP levels. Specifically, Drp1 is genetically required for border cell migration, and Drp1-mediated mitochondrial fission promotes formation of leading protection, likely through its regulation of ATP levels. Reduction of ATP levels重要的是，我们发现在边界细胞迁移过程中，Rhoa/Rock信号对于肌动蛋白和肌球蛋白动力学至关重要，可以通过调节DRP1的募集到线粒体对线粒体的募集来执行其对线粒体裂变的影响。肌动球蛋白功能，导致爆发性和迁移行为。
Collective migration plays critical roles in developmental, physiological and pathological processes, and requires a dynamic actomyosin network for cell shape change, cell adhesion and cell-cell communication. The dynamic network of mitochondria in individual cells is regulated by mitochondrial fission and fusion, and is required for cellular processes including cell metabolism, apoptosis and cell division. But whether mitochondrial dynamics interplays with and regulates actomyosin dynamics during collective migration is not clear. Here, we demonstrate that proper regulation of mitochondrial dynamics is critical for collective migration of Drosophila border cells during oogenesis, and misregulation of fission or fusion results in reduction of ATP levels. Specifically, Drp1 is genetically required for border cell migration, and Drp1-mediated mitochondrial fission promotes formation of leading protrusion, likely through its regulation of ATP levels. Reduction of ATP levels by drug treatment also affects protrusion formation as well as actomyosin dynamics. Importantly, we find that RhoA/ROCK signaling, which is essential for actin and myosin dynamics during border cell migration, could exert its effect on mitochondrial fission through regulating Drp1’s recruitment to mitochondria. These findings suggest that RhoA/ROCK signaling may couple or coordinate actomyosin dynamics with mitochondrial dynamics to achieve optimal actomyosin function, leading to protrusive and migratory behavior.
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影响因子：
4.6
作者：
Kim HJ;Shaker MR;Cho B;Cho HM;Kim H;Kim JY;Sun W
通讯作者：
Sun W
影响因子：
9.2
作者：
Llense, Flora;Martin-Blanco, Enrique
通讯作者：
Martin-Blanco, Enrique
影响因子：
5.5
作者：
Mao X;Gu Y;Sui X;Shen L;Han J;Wang H;Xi Q;Zhuang Q;Meng Q;Wu G
通讯作者：
Wu G
影响因子：
4.6
作者：
Qu, Chen;Sun, Jiejie;Song, Linsheng
通讯作者：
Song, Linsheng
DOI：
10.1083/jcb.133.3.617
发表时间：
1996-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Murphy AM;Montell DJ
通讯作者：
Montell DJ