Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.
Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.
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DOI：
10.1289/ehp.1306880
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发表时间：
2014-02
影响因子：
10.4
通讯作者：
Steenland K
中科院分区：
文献类型：
--
作者：
Vermeulen R;Silverman DT;Garshick E;Vlaanderen J;Portengen L;Steenland K
背景：柴油发动机废气（DEE）最近被列为已知的人类致癌物。目的：我们得出了 DEE 和肺癌死亡率的元暴露-反应曲线 (ERC)，并根据假设的职业和环境暴露情景估计了肺癌死亡率的终生超额风险 (ELR)。方法：我们根据三项大型职业队列研究（包括两项针对卡车运输行业工人的研究和一项针对矿工的研究）报告的相对风险（RR）估计，对肺癌死亡率和元素碳累积暴露（EC）（DEE 的一种替代指标）进行了荟萃回归。根据导出的风险函数，我们计算了几种终生职业和环境暴露情景的 ELR，并计算了因 DEE 导致的每年肺癌死亡的比例。结果：根据线性荟萃回归模型，我们估计累积 EC 每增加 1 μg/m3 年，肺癌死亡率的 lnRR 为 0.00098（95% CI：0.00055，0.0014）。各个研究的相应 lnRR 范围为 0.00061 至 0.0012。终生职业接触 1、10 和 25 μg/m3 EC 时，80 岁之前因肺癌死亡的估计人数分别为每 10,000 人中 17 人、200 人和 689 人。对于终生暴露于 0.8 μg/m3 EC 的环境，我们估计每 10,000 人中有 21 人因肺癌死亡。根据对过去职业和环境暴露的广泛假设，我们估计每年大约 6% 的肺癌死亡可能是由于 DEE 暴露造成的。结论：来自美国三项职业队列研究的综合数据表明，工作场所和室外空气中常见的 DEE 水平似乎会造成相当大的终生肺癌风险，高于美国和欧洲通常可接受的限度，根据职业人群和一般人群的终生接触水平，通常分别将其设定为 1/1,000 和 1/100,000。引用：Vermeulen R、Silverman DT、Garshick E、Vlaanderen J、Portengen L、Steenland K. 2014。基于三个职业队列的数据对柴油发动机废气和肺癌死亡率的暴露反应估计。环境健康视角 122：172–177； http://dx.doi.org/10.1289/ehp.1306880
Background: Diesel engine exhaust (DEE) has recently been classified as a known human carcinogen. Objective: We derived a meta-exposure–response curve (ERC) for DEE and lung cancer mortality and estimated lifetime excess risks (ELRs) of lung cancer mortality based on assumed occupational and environmental exposure scenarios. Methods: We conducted a meta-regression of lung cancer mortality and cumulative exposure to elemental carbon (EC), a proxy measure of DEE, based on relative risk (RR) estimates reported by three large occupational cohort studies (including two studies of workers in the trucking industry and one study of miners). Based on the derived risk function, we calculated ELRs for several lifetime occupational and environmental exposure scenarios and also calculated the fractions of annual lung cancer deaths attributable to DEE. Results: We estimated a lnRR of 0.00098 (95% CI: 0.00055, 0.0014) for lung cancer mortality with each 1-μg/m3-year increase in cumulative EC based on a linear meta-regression model. Corresponding lnRRs for the individual studies ranged from 0.00061 to 0.0012. Estimated numbers of excess lung cancer deaths through 80 years of age for lifetime occupational exposures of 1, 10, and 25 μg/m3 EC were 17, 200, and 689 per 10,000, respectively. For lifetime environmental exposure to 0.8 μg/m3 EC, we estimated 21 excess lung cancer deaths per 10,000. Based on broad assumptions regarding past occupational and environmental exposures, we estimated that approximately 6% of annual lung cancer deaths may be due to DEE exposure. Conclusions: Combined data from three U.S. occupational cohort studies suggest that DEE at levels common in the workplace and in outdoor air appear to pose substantial excess lifetime risks of lung cancer, above the usually acceptable limits in the United States and Europe, which are generally set at 1/1,000 and 1/100,000 based on lifetime exposure for the occupational and general population, respectively. Citation: Vermeulen R, Silverman DT, Garshick E, Vlaanderen J, Portengen L, Steenland K. 2014. Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts. Environ Health Perspect 122:172–177; http://dx.doi.org/10.1289/ehp.1306880
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影响因子：
10.4
作者：
Garshick E;Laden F;Hart JE;Davis ME;Eisen EA;Smith TJ
通讯作者：
Smith TJ
影响因子：
13.6
作者：
Moehner, Matthias;Kersten, Norbert;Gellissen, Johannes
通讯作者：
Gellissen, Johannes
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
DOI：
10.1093/jnci/djs034
发表时间：
2012-06-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Silverman DT;Samanic CM;Lubin JH;Blair AE;Stewart PA;Vermeulen R;Coble JB;Rothman N;Schleiff PL;Travis WD;Ziegler RG;Wacholder S;Attfield MD
通讯作者：
Attfield MD
影响因子：
8.8
作者：
Brown, Terry;Darnton, Andy;Rushton, Lesley
通讯作者：
Rushton, Lesley