Lung cancer and elemental carbon exposure in trucking industry workers.
Lung cancer and elemental carbon exposure in trucking industry workers.
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DOI：
10.1289/ehp.1204989
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发表时间：
2012-09
影响因子：
10.4
通讯作者：
Smith TJ
中科院分区：
文献类型：
--
作者：
Garshick E;Laden F;Hart JE;Davis ME;Eisen EA;Smith TJ
背景：基于对职业暴露工人的研究，柴油机废气被认为是一种可能的肺癌致癌物。在这些研究中确定肺癌风险的努力部分受到缺乏定量暴露估计的限制。目的：我们进行了一项回顾性队列研究，以评估美国卡车运输业工人的肺癌死亡风险。元素碳（EC）被用作暴露于柴油车、交通和装卸码头作业的发动机废气的替代物。方法：1985年，在美国卡车运输业工会组织中雇用的31,135名男性工人的工作记录。一个基于国家暴露评估的统计模型被用来估计历史上与工作有关的EC暴露。肺癌死亡率被确定到2000年，并使用比例风险模型估计与累积和平均EC的关联。结果如下：就业时间与肺癌风险呈负相关，这与健康工人幸存者效应和由普遍雇佣者组成的队列一致。在调整就业时间后，我们注意到一个线性的假设-反应关系的建议。对于每1，000 µg/m3个月的累积EC，基于5年暴露滞后，风险比（HR）为1.07 [95%置信区间（CI）：0.99，1.15]，10年暴露滞后的相关性相似[HR = 1.09（95% CI：0.99，1.20）]。平均暴露与相对风险无关。结论：卡车运输业工人的肺癌死亡率增加与就业时间调整后的负混杂累积接触EC。
Background: Diesel exhaust has been considered to be a probable lung carcinogen based on studies of occupationally exposed workers. Efforts to define lung cancer risk in these studies have been limited in part by lack of quantitative exposure estimates. Objective: We conducted a retrospective cohort study to assess lung cancer mortality risk among U.S. trucking industry workers. Elemental carbon (EC) was used as a surrogate of exposure to engine exhaust from diesel vehicles, traffic, and loading dock operations. Methods: Work records were available for 31,135 male workers employed in the unionized U.S. trucking industry in 1985. A statistical model based on a national exposure assessment was used to estimate historical work-related exposures to EC. Lung cancer mortality was ascertained through the year 2000, and associations with cumulative and average EC were estimated using proportional hazards models. Results: Duration of employment was inversely associated with lung cancer risk consistent with a healthy worker survivor effect and a cohort composed of prevalent hires. After adjusting for employment duration, we noted a suggestion of a linear exposure–response relationship. For each 1,000-µg/m3 months of cumulative EC, based on a 5-year exposure lag, the hazard ratio (HR) was 1.07 [95% confidence interval (CI): 0.99, 1.15] with a similar association for a 10-year exposure lag [HR = 1.09 (95% CI: 0.99, 1.20)]. Average exposure was not associated with relative risk. Conclusions: Lung cancer mortality in trucking industry workers increased in association with cumulative exposure to EC after adjusting for negative confounding by employment duration.
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影响因子：
5
作者：
CASS, GR;CONKLIN, MH;HUNTZICKER, JJ
通讯作者：
HUNTZICKER, JJ
DOI：
10.1202/435.1
发表时间：
2003-07-01
期刊：
AIHA JOURNAL
影响因子：
--
作者：
Bailey, CR;Somers, JH;Steenland, K
通讯作者：
Steenland, K
影响因子：
5
作者：
Brown, SC;Schonbeck, MF;Ruttenber, AJ
通讯作者：
Ruttenber, AJ
卡车行业工人的肺癌和车辆排气。
影响因子：
10.4
作者：
Garshick, Eric;Laden, Francine;Hart, Jaime E.;Rosner, Bernard;Davis, Mary E.;Eisen, Ellen A.;Smith, Thomas J.
通讯作者：
Smith, Thomas J.
DOI：
10.1080/15459620902914349
发表时间：
2009-01-01
影响因子：
2
作者：
Davis, Mary E.;Laden, Francine;Smith, Thomas J.
通讯作者：
Smith, Thomas J.