A Supramolecular Approach to Nanoscale Motion: Polymersome-Based Self-Propelled Nanomotors.
A Supramolecular Approach to Nanoscale Motion: Polymersome-Based Self-Propelled Nanomotors.
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DOI：
10.1021/acs.accounts.8b00199
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发表时间：
2018-09-18
影响因子：
18.3
通讯作者：
Wilson DA
中科院分区：
文献类型：
--
作者：
Ortiz-Rivera I;Mathesh M;Wilson DA
自主微米级和纳米级系统彻底改变了科学家展望未来的方式，开辟了通过更具生物启发的途径来处理和解决问题的新领域。然而，为了实现更高复杂性、卓越的输出控制和多功能性的系统，深入研究影响微纳米电机行为的不同因素至关重要。从基本角度来看，微电机和纳米电机的机械响应仍需要进一步研究，以便更好地了解这些系统的确切运行方式以及可以组合到一个系统中以实现最佳响应的不同运动机制。从设计工程的角度来看，考虑到这些设备在生物医学应用中的潜力，必须解决目前制造的有源系统的兼容性、可降解性、特异性、灵敏度、响应性和效率。尽管如此，对于迄今为止研究的微型和纳米电机来说，在所有这些领域优化系统是一项具有挑战性的任务，因为它们大多数由不利于进一步化学或物理操作的材料或设计组成。随着自供电系统这个新领域的发展，对不同尺寸、形状、化学功能和架构的电机原型的需求变得越来越重要，这不仅将定义有源系统的供电方式，还将定义电机的制造方法。自下而上的超分子方法最近已成为开发活性结构的绝佳候选者，这些活性结构允许化学或物理功能化、形状转变和区室化，在提供软界面以改善分子识别和细胞摄取的结构中。我们的小组率先通过制造能够以底物浓度依赖性方式显示主动运动的口细胞或管状马达，使用超分子结构作为催化推进系统。这种行为证明了自下而上组件在微米或纳米尺度上为运动提供动力的潜力，并且系统可以在分子水平上轻松调整和控制。在本报告中，我们重点介绍了我们为了解和优化催化动力聚合物电机的设计而采取的步骤。我们的研究重点是解决运动结构、运动激活、方向控制和生物整合的重要性。虽然我们的工作支持超分子结构用于活性系统设计的可行性，但我们坚信，我们仍处于揭示超分子化学在微纳米电机领域的全部潜力的初始阶段。我们期待在不久的将来使用这种方法来开发多功能和刺激响应系统。
Autonomous micro- and nanoscale systems have revolutionized the way scientists look into the future, opening up new frontiers to approach and solve problems via a more bioinspired route. However, to achieve systems with higher complexity, superior output control, and multifunctionality, an in-depth study of the different factors that affect micro- and nanomotor behavior is crucial. From a fundamental perspective, the mechanical response of micro- and nanomotors still requires further study in order to have a better understanding of how exactly these systems operate and the different mechanisms of motion that can be combined into one system to achieve an optimal response. From a design engineering point of view, compatibility, degradability, specificity, sensitivity, responsiveness, and efficiency of the active systems fabricated to this point have to be addressed, with respect to the potential of these devices for biomedical applications. Nonetheless, optimizing the system with regards to all these areas is a challenging task with the micro- and nanomotors studied to date, as most of them consist of materials or designs that are unfavorable for further chemical or physical manipulation. As this new field of self-powered systems moves forward, the need for motor prototypes with different sizes, shapes, chemical functionalities, and architectures becomes increasingly important and will define not only the way active systems are powered, but also the methods for motor fabrication. Bottom-up supramolecular approaches have recently emerged as great candidates for the development of active structures that allow for chemical or physical functionalization, shape transformation, and compartmentalization, in a structure that provides a soft interface to improve molecular recognition and cell uptake. Our group pioneers the use of supramolecular structures as catalytically propelled systems via the fabrication of stomatocyte or tubular-shaped motors capable of displaying active motion in a substrate concentration-dependent fashion. This behavior demonstrates the potential of bottom-up assemblies for powering motion at the micro- or nanoscale, with a system that can be readily tuned and controlled at the molecular level. In this Account, we highlight the steps we have taken in order to understand and optimize the design of catalytically powered polymersome-based motors. Our research has been focused on addressing the importance of motor architecture, motion activation, direction control, and biological integration. While our work supports the feasibility of supramolecular structures for the design of active systems, we strongly believe that we are still in the initial stages of unveiling the full potential of supramolecular chemistry in the micro- and nanomotor field. We look forward to using this approach for the development of multifunctional and stimuli-responsive systems in the near future.
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影响因子：
18.2
作者：
Nijemeisland, Marlies;Abdelmohsen, Loai K. E. A.;Huck, Wilhelm T. S.;Wilson, Daniela A.;van Hest, Jan C. M.
通讯作者：
van Hest, Jan C. M.
影响因子：
16.6
作者：
Rikken, R. S. M.;Engelkamp, H.;Nolte, R. J. M.;Maan, J. C.;van Hest, J. C. M.;Wilson, D. A.;Christianen, P. C. M.
通讯作者：
Christianen, P. C. M.
影响因子：
0.9
作者：
PURCELL, EM
通讯作者：
PURCELL, EM
影响因子：
2.4
作者：
Ebbens, Stephen;Jones, Richard A. L.;Howse, Jonathan R.
通讯作者：
Howse, Jonathan R.
影响因子：
8.6
作者：
Hong, Yiying;Blackman, Nicole M. K.;Velegol, Darrell
通讯作者：
Velegol, Darrell