Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly.
Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly.
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DOI：
10.1038/ncomms12606
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发表时间：
2016-08-25
影响因子：
16.6
通讯作者：
Christianen, P. C. M.
中科院分区：
文献类型：
--
作者：
Rikken, R. S. M.;Engelkamp, H.;Nolte, R. J. M.;Maan, J. C.;van Hest, J. C. M.;Wilson, D. A.;Christianen, P. C. M.
聚合物囊泡是由两亲性嵌段共聚物自组装而成的双层囊泡。它们是具有可调节性质的通用纳米胶囊，例如柔性、渗透性、尺寸和功能性。然而，到目前为止，还没有控制其形状的方法。在这里，我们展示了一个完全理解的过程，通过一个平衡过程精确控制聚合物囊泡的形状。仔细选择渗透压和渗透性启动受控的放气，导致短暂的胶囊形状，然后再膨胀的聚合物囊泡。朝向口细胞，碗状囊泡的形状转变，用磁双折射探测，使我们能够在相图中的任何中间形状停止该过程。不同形态的定量电子显微镜分析表明，这种形状转变通过长期预测的滞后收缩-膨胀轨迹进行，这可以理解的弯曲能量。由于高度的可控性和可预测性，这项研究提供了设计规则，访问所有可能的不同形状的聚合物囊泡。 聚合物囊泡用于许多应用，从药物递送到微流体，但控制它们的形状是困难的。在这里，Christianen和同事通过一个失衡过程精确地控制了聚合物体的形状，并完全理解了这个过程的机制。
Polymersomes are bilayer vesicles, self-assembled from amphiphilic block copolymers. They are versatile nanocapsules with adjustable properties, such as flexibility, permeability, size and functionality. However, so far no methodological approach to control their shape exists. Here we demonstrate a mechanistically fully understood procedure to precisely control polymersome shape via an out-of-equilibrium process. Carefully selecting osmotic pressure and permeability initiates controlled deflation, resulting in transient capsule shapes, followed by reinflation of the polymersomes. The shape transformation towards stomatocytes, bowl-shaped vesicles, was probed with magnetic birefringence, permitting us to stop the process at any intermediate shape in the phase diagram. Quantitative electron microscopy analysis of the different morphologies reveals that this shape transformation proceeds via a long-predicted hysteretic deflation–inflation trajectory, which can be understood in terms of bending energy. Because of the high degree of controllability and predictability, this study provides the design rules for accessing polymersomes with all possible different shapes. Polymersomes are used in many applications, ranging from drug delivery to microfluidics, but controlling their shape is difficult. Here, Christianen and co-workers have precisely controlled polymersome shape via an out-of-equilibrium process and fully understood the mechanism of this procedure.
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影响因子：
17.1
作者：
Robertson, James D.;Yealland, Guy;Battaglia, Giuseppe
通讯作者：
Battaglia, Giuseppe
影响因子：
1.8
作者：
Le Meins, J. -F.;Sandre, O.;Lecommandoux, S.
通讯作者：
Lecommandoux, S.
DOI：
10.1073/pnas.1308345110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Kolhar, Poornima;Anselmo, Aaron C.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
56.9
作者：
Discher, BM;Won, YY;Hammer, DA
通讯作者：
Hammer, DA
DOI：
10.1051/jp2:1992188
发表时间：
1992-05-01
期刊：
JOURNAL DE PHYSIQUE II
影响因子：
--
作者：
HEINRICH, V;BRUMEN, M;ZEKS, B
通讯作者：
ZEKS, B