Research progress of circRNA in malignant tumour metabolic reprogramming.
Research progress of circRNA in malignant tumour metabolic reprogramming.
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DOI：
10.1080/15476286.2023.2247877
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发表时间：
2023-01
期刊：
影响因子：
4.1
通讯作者：
Yu, Lan
中科院分区：
文献类型：
--
作者：
Geng, Yikun;Wang, Min;Wu, Zhouying;Jia, Jianchao;Yang, Tingyu;Yu, Lan
癌症是一种多因素的全身性恶性疾病，严重威胁人类健康，给世界经济造成沉重负担。代谢重编程是恶性肿瘤的重要标志之一，为肿瘤的发生和发展提供必要的营养，因此，尽管代谢机制错综复杂，但近年来已成为研究热点。环状RNA(CircRNA)通过多种分子机制影响癌细胞代谢，在促进或抑制肿瘤发生中发挥重要作用。由于CircRNA的结构特征，它非常稳定，可以作为生物标志物。本文对CircRNA的特性和生物学功能进行了分析和总结，并对CircRNA在肿瘤代谢重编程中的重要作用进行了全面的综述和讨论。这一综述将为开发新的抗癌治疗靶点、挖掘肿瘤诊断和预后标志物提供新的思路，并将为其他研究人员设计CircRNA相关实验和开发抗肿瘤药物提供指导。
Cancer is a multi-factor systemic malignant disease, which has seriously threatened human health and created a heavy burden on the world economy. Metabolic reprogramming, one of the important signs of malignant tumours, provides necessary nutrition for tumorigenesis and cancer development; thus, it has recently become a research hot spot, even though the metabolic mechanism is quite intricate. Circular RNA (circRNA) affects cancer cell metabolism through various molecular mechanisms, playing an important role in promoting or suppressing cancer. Because of the structure characteristics, circRNA is quite stable, and can be utilized as biomarkers. In this review, we analysed and summarized the characteristics and biological functions of circRNA and comprehensively reviewed and discussed the important role of circRNA in cancer metabolic reprogramming. This review will provide new ideas for developing new anti-cancer therapeutic targets, mining cancer diagnostic and prognostic markers, and will provide guidance for other researchers to design circRNA-related experiments and develop anti-tumour drugs.
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